CAJ | 학술논문

目的对运动疗法干预癌因性疲乏的有效性及安全性进行评价. 方法计算机检索Cochrane图书馆、JBI Database of Systematic Reviews、MEDLINE、EMbase、CINAHL、中国期刊全文数据库、中国生物医学文献数据库、万方医学数据库等数据库,筛选提取符合标准的系统评价/Meta分析,用总体质量评估问卷(Overview Quality Assessment Questionnaire,OQAQ)评价其方法学质量,用描述性分析的方法分析资料,主要结局指标包括癌因性疲乏程度评分,次要结局指标包括运动的依从性和不良事件发生率. 结果共纳入14篇系统评价/Meta分析,方法学质量评分为5~7分者12篇. 6篇系统评价/Meta分析评价了有氧运动的干预效果,与对照组相比,有氧运动能有效缓解癌因性疲乏,尤其是乳腺癌患者的癌因性疲乏;7篇文献结果显示运动能有效缓解正在接受抗肿瘤治疗患者的癌因性疲乏;7篇文献报道了所纳入研究的运动干预的依从性;4篇文献报道了所纳入研究的不良事件发生情况,所报道的不良事件极少与运动直接相关. 结论运动疗法可用于肿瘤患者癌因性疲乏的干预,安全性较好.
목적 대운동요법간예암인성피핍적유효성급안전성진행평개. 방법 계산궤검색Cochrane도서관、JBI Database of Systematic Reviews、MEDLINE、EMbase、CINAHL、 중국기간전문수거고、중국생물의학문헌수거고、만방의학수거고등수거고,사선제취부합표준적계통평개/Meta분석,용총체질량평고문권(Overview Quality Assessment Questionnaire,OQAQ)평개기방법학질량,용묘술성분석적방법분석자료,주요결국지표포괄암인성피핍정도평분,차요결국지표포괄운동적의종성화불량사건발생솔. 결과 공납입14편계통평개/Meta분석,방법학질량평분위5~7분자12편. 6편계통평개/Meta분석평개료유양운동적간예효과,여대조조상비,유양운동능유효완해암인성피핍,우기시유선암환자적암인성피핍;7편문헌결과현시운동능유효완해정재접수항종류치료환자적암인성피핍;7편문헌보도료소납입연구적운동간예적의종성;4편문헌보도료소납입연구적불량사건발생정황,소보도적불량사건겁소여운동직접상관. 결론 운동요법가용우종류환자암인성피핍적간예,안전성교호.
Objective To evaluate the efficiency and safety of exercise interventions on cancer related fatigue. Methods Cochrane Library, JBI Database of Systematic Reviews, MEDLINE, EMbase, CINAHL, Chinese Journal Full- text Database, Chinese Biomedical Literature Database, and Wanfang Databse were searched from the inception to November 2014 to screen the systematic review and Meta-analysis conforming to the inclusion criteria. Two authors independently appraised their methodological qualities with Overview Quality Assessment Questionnaire (OQAQ), and analyzed the data using descriptive analysis. The primary outcome included the scaling of cancer related fatigue, the secondary outcome included adherence to exercise intervention and the incidence of adverse events. Results Fourteen systematic review/Meta-analysis were identified, twelve of them had a high methodological quality (Scoring 5-7). Six systematic review/Meta-analysis found that aerobic exercise could effectively alleviate cancer related fatigue, especially for breast cancer patients;seven articles showed that exercise could modulate cancer related fatigue of patients under active treatments;seven articles reported the compliance to the exercise intervention, four articles reported adverse events occurring during the intervention, very few of them resulted directly from the exercise intervention. Conclusions Exercise intervention can modulate cancer related fatigue with good safety.