CAJ | 학술논문

目的考察阿司匹林和华法林对心房颤动（ AF）患者抗栓治疗的疗效。方法选取2013年7月～2014年10月进入我院的患者100名，根据双盲随机化的原则，将患者分为阿司匹林对照组和华法林治疗组。通过观察患者治疗前后的症状变化，比较两者用药的治疗效果；测定两组患者治疗前后的Fbg、D-dimer及HCT水平，观察对照组和治疗组患者的凝血活性变化；采用放射免疫法检测血浆中6-keto-PGF1 a和TXB2的含量并计算比值，考察阿司匹林和华法林对前列腺环素和血栓素平衡的影响；采用放射免疫法，考察AF患者治疗前后血浆中BNP的含量变化；通过测定血浆中CRP的水平及TNF-α和L-6的水平，比较治疗前后对照组和治疗组患者的炎症反应。结果经规范化治疗后，对照组和治疗组患者的血栓前状态均得到较大改善。临床疗效判定结果表明，阿司匹林和华法林均具有良好的抗栓效果，华法林疗效优于阿司匹林。与治疗前相比，抗栓治疗后AF患者血浆中与凝血活性相关的Fbg、D-dimer及HCT水平明显下降（P＜0．05），前列腺环素和血栓素恢复平衡，与炎症相关的BNP、CRP水平及TNF-α和L-6水平均明显下降（P＜0．05）。结论阿司匹林和华法林均可用于AF患者的血栓防治，华法林的治疗效果优于阿司匹林。
목적고찰아사필림화화법림대심방전동（ AF）환자항전치료적료효。방법선취2013년7월～2014년10월진입아원적환자100명，근거쌍맹수궤화적원칙，장환자분위아사필림대조조화화법림치료조。통과관찰환자치료전후적증상변화，비교량자용약적치료효과；측정량조환자치료전후적Fbg、D-dimer급HCT수평，관찰대조조화치료조환자적응혈활성변화；채용방사면역법검측혈장중6-keto-PGF1 a화TXB2적함량병계산비치，고찰아사필림화화법림대전렬선배소화혈전소평형적영향；채용방사면역법，고찰AF환자치료전후혈장중BNP적함량변화；통과측정혈장중CRP적수평급TNF-α화L-6적수평，비교치료전후대조조화치료조환자적염증반응。결과경규범화치료후，대조조화치료조환자적혈전전상태균득도교대개선。림상료효판정결과표명，아사필림화화법림균구유량호적항전효과，화법림료효우우아사필림。여치료전상비，항전치료후AF환자혈장중여응혈활성상관적Fbg、D-dimer급HCT수평명현하강（P＜0．05），전렬선배소화혈전소회복평형，여염증상관적BNP、CRP수평급TNF-α화L-6수평균명현하강（P＜0．05）。결론아사필림화화법림균가용우AF환자적혈전방치，화법림적치료효과우우아사필림。
Objective To observe the effect of warfarin compared to aspirin in patients with atrial fi-brillation.Methods A randomized approach was study .Patients with atrial fibrillation were treated with aspi-rin ( 50 cases ) and warfarin ( 50 cases ) , respectively .The changes in syndrome were observed .The levels of Fbg,D-dimer,HCT,6-keto-PGF1 a and TXB2 in plasma were measured .Also,BNP,TNF-αand L-6 levels were measured .Results The syndromes on patients with atrial fibrillation were improved obviously .The plas-ma Fbg,D-dimer,HCT,BNP and TNF-αlevels in patients treated with aspirin or warfarin were significant difference ( P<0 .05 ) compared to the levels before treatment .Prostaglandins and thromboxane restore bal-ance .Conclusion From the results of our study , it is evident that patients treated with warfarin are better than patients treated with aspirin .