四川医学
四川醫學
사천의학
Sichuan Medical Journal
2015年
10期
1433-1436
,共4页
缺血性脑卒中%高敏C-反应蛋白%死亡%残疾
缺血性腦卒中%高敏C-反應蛋白%死亡%殘疾
결혈성뇌졸중%고민C-반응단백%사망%잔질
ischemic stroke%high sensitivity C-reactive protein%death%disability
目的 了解缺血性脑卒中急性期高敏C反应蛋白( hs-CRP)水平的变化特征,探讨其与预后的关系. 方法前瞻性连续登记2012年9月1日至2014年8月31日我科收治、发病时间≤24h的缺血性脑卒中患者,于入院时或次晨测量血浆hs-CRP水平;收集可能影响hs-CRP和临床结局相关的因素;随访住院期间及发病后3个月末患者的死亡和残疾情况. 结果 本研究共纳入245例缺血性脑卒中急性期患者,入院时hs-CRP为0. 15~40. 56 mg/L,中位值5. 0mg/L,四分位间距2. 0~10. 0mg/L;入院时hs-CRP>3mg/L是患者住院期间死亡、3个月死亡/残疾独立危险因素,与hs-CRP≤3mg/L患者相比,死亡风险分别增加了1. 578倍、1. 266倍. 结论 入院时hs-CRP是缺血脑卒中住院期间死亡、3个月死亡和残疾独立影响因素.
目的 瞭解缺血性腦卒中急性期高敏C反應蛋白( hs-CRP)水平的變化特徵,探討其與預後的關繫. 方法前瞻性連續登記2012年9月1日至2014年8月31日我科收治、髮病時間≤24h的缺血性腦卒中患者,于入院時或次晨測量血漿hs-CRP水平;收集可能影響hs-CRP和臨床結跼相關的因素;隨訪住院期間及髮病後3箇月末患者的死亡和殘疾情況. 結果 本研究共納入245例缺血性腦卒中急性期患者,入院時hs-CRP為0. 15~40. 56 mg/L,中位值5. 0mg/L,四分位間距2. 0~10. 0mg/L;入院時hs-CRP>3mg/L是患者住院期間死亡、3箇月死亡/殘疾獨立危險因素,與hs-CRP≤3mg/L患者相比,死亡風險分彆增加瞭1. 578倍、1. 266倍. 結論 入院時hs-CRP是缺血腦卒中住院期間死亡、3箇月死亡和殘疾獨立影響因素.
목적 료해결혈성뇌졸중급성기고민C반응단백( hs-CRP)수평적변화특정,탐토기여예후적관계. 방법전첨성련속등기2012년9월1일지2014년8월31일아과수치、발병시간≤24h적결혈성뇌졸중환자,우입원시혹차신측량혈장hs-CRP수평;수집가능영향hs-CRP화림상결국상관적인소;수방주원기간급발병후3개월말환자적사망화잔질정황. 결과 본연구공납입245례결혈성뇌졸중급성기환자,입원시hs-CRP위0. 15~40. 56 mg/L,중위치5. 0mg/L,사분위간거2. 0~10. 0mg/L;입원시hs-CRP>3mg/L시환자주원기간사망、3개월사망/잔질독립위험인소,여hs-CRP≤3mg/L환자상비,사망풍험분별증가료1. 578배、1. 266배. 결론 입원시hs-CRP시결혈뇌졸중주원기간사망、3개월사망화잔질독립영향인소.
Objective In the study, we investigated high sensitivity C-reactive protein and clinical characteristics in pa-tients with acute ischemic stroke and explored the association between high sensitivity C-reactive protein and outcomes in acute is-chemic stroke. Methods Prospectively registered consecutive cases of acute ischemic stroke at the neurology department of Wen-jiang People's Hospital from September. 01, 2012 to August. 31, 2014. The patients with acute ischemic stroke within 24 hours of symptom onset were included. The level of serum high sensitivity C-reactive protein on admission or the next morning was meas-ured. Other relevant factors influencing level of high sensitivity C-reactive protein and ischemic stroke outcomes were also collect-ed, and outcomes including death or disability were followed up during hospital and at the end of 3 month. Results 245 patients with acute ischemic stroke were involved, the level of high sensitivity C-reactive protein was from 0. 15 mg/L to 40. 56mg/L, the median was 5. 0mg/L, and quartile was 2. 0~10. 0mg/L. hs-CRP>3mg/L, it became an independent risk factor for death or dis-ability at the end of 3 month. Compared to the lower concentration, which was less than 3 mg/L, the risk of death for these pa-tients was increased by1. 578 and 1. 266, respectively. Conclusion The high sensitivity C-reactive protein on admission was the independent predictive for death/disability at the end of 3 month in acute ischemic stroke.
