四川医学
四川醫學
사천의학
Sichuan Medical Journal
2015年
10期
1430-1432
,共3页
右美托咪定%机械通气%记忆%焦虑%抑郁
右美託咪定%機械通氣%記憶%焦慮%抑鬱
우미탁미정%궤계통기%기억%초필%억욱
dexmedetomidine%mechanical ventilation%recall%anxiety%depression
目的 评估使用右美托咪定镇静对机械通气患者记忆和情绪的影响. 方法 采用随机对照研究,将32例ICU气管插管机械通气的患者随机分为两组,分别应用右美托咪定和咪达唑仑镇静,分别采用ICU不适经历记忆调查问卷和医院焦虑抑郁量表评估患者ICU记忆和焦虑抑郁情绪,并观察两组患者机械通气时间、ICU住院时间以及谵妄的发生率. 结果 右美托咪定组患者有记忆的ICU不适经历事件数目的中位数显著大于咪达唑仑组,差异有统计学意义(P<0. 05),两组患者医院焦虑抑郁量表评分结果差异无统计学意义(P>0. 05),右美托咪定组机械通气时间较咪达唑仑组缩短,两组患者ICU留住时间相似,右美托咪定组谵妄的发生率更低. 结论 右美托咪定可增强患者对ICU不适经历的记忆,但未增加焦虑、抑郁情绪的发生,未对临床预后产生不良影响.
目的 評估使用右美託咪定鎮靜對機械通氣患者記憶和情緒的影響. 方法 採用隨機對照研究,將32例ICU氣管插管機械通氣的患者隨機分為兩組,分彆應用右美託咪定和咪達唑崙鎮靜,分彆採用ICU不適經歷記憶調查問捲和醫院焦慮抑鬱量錶評估患者ICU記憶和焦慮抑鬱情緒,併觀察兩組患者機械通氣時間、ICU住院時間以及譫妄的髮生率. 結果 右美託咪定組患者有記憶的ICU不適經歷事件數目的中位數顯著大于咪達唑崙組,差異有統計學意義(P<0. 05),兩組患者醫院焦慮抑鬱量錶評分結果差異無統計學意義(P>0. 05),右美託咪定組機械通氣時間較咪達唑崙組縮短,兩組患者ICU留住時間相似,右美託咪定組譫妄的髮生率更低. 結論 右美託咪定可增彊患者對ICU不適經歷的記憶,但未增加焦慮、抑鬱情緒的髮生,未對臨床預後產生不良影響.
목적 평고사용우미탁미정진정대궤계통기환자기억화정서적영향. 방법 채용수궤대조연구,장32례ICU기관삽관궤계통기적환자수궤분위량조,분별응용우미탁미정화미체서륜진정,분별채용ICU불괄경력기억조사문권화의원초필억욱량표평고환자ICU기억화초필억욱정서,병관찰량조환자궤계통기시간、ICU주원시간이급섬망적발생솔. 결과 우미탁미정조환자유기억적ICU불괄경역사건수목적중위수현저대우미체서륜조,차이유통계학의의(P<0. 05),량조환자의원초필억욱량표평분결과차이무통계학의의(P>0. 05),우미탁미정조궤계통기시간교미체서륜조축단,량조환자ICU류주시간상사,우미탁미정조섬망적발생솔경저. 결론 우미탁미정가증강환자대ICU불괄경력적기억,단미증가초필、억욱정서적발생,미대림상예후산생불량영향.
Objective To assese recall and emotion of patients with mechanical ventilation after dexmedetomidine seda-tion. Methods The randomized controlled trial was conducted. Thirty-two patients with mechanical ventilation were randomly di-vided into Dexmedetomidine and Midazolam for sedation. The intensive care unit( ICU) Stressful Experiences Questionnaire,Hospi-tal Anxiety and Depression Scale were administered to assess recall,anxiety and depression. The length of mechanical ventilation, the length of ICU and the incidence of delirium were observed. Results The median number of experiences remembered by dexmedetomidine patients was greater than that of midazolam patients. Manifestations of anxiety and depression were similar be-tween the groups. The length of mechanical ventilation of dexmedetomidine group were shorter than that of midazolam group. The length of ICU of two groups was similar. The incidence of delirium of dexmedetomidine group was lower than that of midazolam. Conclusion Patients received dexmedetomidine were associated with greater recall of ICU experiences,but were no more likely to develop traits of anxiety or depression. Dexmedetomidine was not found to have adverse effects on clinical outcomes.
