CAJ | 학술논문

目的探讨血清β-羟丁酸(β-HB)和乳酸( LAC)水平变化在糖尿病酮症酸中毒( DKA)诊断中的临床价值.方法在贝克曼AU2700全自动生化分析仪上对57例糖尿病非酮症患者( NDK组)、63例糖尿病酮症酸中毒患者( DKA组)、49例酮症混合性酸中毒患者( LDKA组)和65 例同期正常体检健康者(对照组)的血清样本进行 β-HB、LAC 和HbA1c检测,并对结果进行统计分析. 结果 NDK组检测血清β-HB、LAC和HbA1c水平高于对照组,DKA组检测血清β-HB、LAC和HbA1c水平明显高于NDK组,组间比较差异有统计学意义(P<0. 05);DKA组和LDKA组检测血清β-HB、LAC和HbA1c水平明显高于对照组,LDKA组检测血清β-HB、LAC和HbA1c水平明显高于NDK组,组间比较差异有统计学意义(P<0. 01);NDK组血清β-HB与LAC联合检测的阳性检出率高于单项阳性检出率,但差异无统计学意义(P>0. 05),DKA组和LDKA组血清 β-HB 与 LAC 联合检测的阳性检出率高于单项阳性检出率,差异有统计学意义(P <0. 05). 结论联合检测血清β-HB和LAC有助于提高DKA诊断率.
목적 탐토혈청β-간정산(β-HB)화유산( LAC)수평변화재당뇨병동증산중독( DKA)진단중적림상개치.방법 재패극만AU2700전자동생화분석의상대57례당뇨병비동증환자( NDK조)、63례당뇨병동증산중독환자( DKA조)、49례동증혼합성산중독환자( LDKA조)화65 례동기정상체검건강자(대조조)적혈청양본진행 β-HB、LAC 화HbA1c검측,병대결과진행통계분석. 결과 NDK조검측혈청β-HB、LAC화HbA1c수평고우대조조,DKA조검측혈청β-HB、LAC화HbA1c수평명현고우NDK조,조간비교차이유통계학의의(P<0. 05);DKA조화LDKA조검측혈청β-HB、LAC화HbA1c수평명현고우대조조,LDKA조검측혈청β-HB、LAC화HbA1c수평명현고우NDK조,조간비교차이유통계학의의(P<0. 01);NDK조혈청β-HB여LAC연합검측적양성검출솔고우단항양성검출솔,단차이무통계학의의(P>0. 05),DKA조화LDKA조혈청 β-HB 여 LAC 연합검측적양성검출솔고우단항양성검출솔,차이유통계학의의(P <0. 05). 결론 연합검측혈청β-HB화LAC유조우제고DKA진단솔.
Objective To explore the changed levels of serum β-hydroxybutyric acid(β-HB) and lactic acid ( LAC) in diagnosis of diabetic ketoacidosis( DKA) . Methods In the Backman AU2700 automatic biochemical analyzer, 57 patients with nonketotic diabetic patients( NDK group) ,63 cases of diabetic ketoacidosis ( DKA group) ,49 cases of mixed acidosis ketosis pa-tients (LDKA group) and 65 cases of normal healthy persons(control group) serumβ-HB,LAC and HbA1c were tested, and the test results were statistical analysised. Results Group NDK serum β-HB,LAC and HbA1c levels were higher than the control group,DKA group levels were significantly higher than that of NDK group,the difference was statistically significant(P<0. 05), DKA group and LDKA group levels were significantly higher than those in the control group,LDK group levels were significantly higher than that of NDK group,there were significant difference (P<0. 01). The joint test of NDK serumβ-HB and LAC positive rate was higher than that of single positive rate,the difference was not statistically significant(P>0. 05),the joint test of DKA group and LDKA group serum β-HB and t LAC he positive rate of was higher than that of single positive rate,the difference was statistically significant(P<0. 05). Conclusion Combined detection of serum β-HB and LAC might improved the diagnostic rate of DKA.