四川医学
四川醫學
사천의학
Sichuan Medical Journal
2015年
10期
1473-1475
,共3页
人乳头瘤病毒%基因分型
人乳頭瘤病毒%基因分型
인유두류병독%기인분형
human papilloma virus%genotyping
目的 分析凉山地区妇女宫颈上皮细胞人乳头瘤病毒的感染情况及其主要型别. 方法 应用反向斑点杂交-基因芯片技术,对2014年1至8月就诊的2643例女性患者宫颈脱落细胞进行23种基因分型检测. 结果 2643份标本检出阳性669例,HPV感染率25. 31%. 其中单一感染检出476例,感染率18. 01%;两种及以上亚型感染检出193例,感染率7. 30%;族别统计958例,其中汉族阳性率24. 16%( 172/712 ) ,彝族阳性率29. 15%( 65/223 ) ,民族分析差异无统计学意义( =2. 24 P>0. 05 ). 检出23种HPV基因亚型,其中低危型阳性167例,以81型阳性最多;高危型阳性763例,阳性例数排前五位的为:52、16、58、53及18型. HPV阳性检出率以≤20岁( 38. 78%)及>51岁( 33. 21%)年龄段较高,感染检出率比较差异有统计学意义( =22. 99,P<0. 01). 结论 凉山地区女性宫颈HPV感染具有独特的地域分布和年龄分布特点,族别之间没有差异.
目的 分析涼山地區婦女宮頸上皮細胞人乳頭瘤病毒的感染情況及其主要型彆. 方法 應用反嚮斑點雜交-基因芯片技術,對2014年1至8月就診的2643例女性患者宮頸脫落細胞進行23種基因分型檢測. 結果 2643份標本檢齣暘性669例,HPV感染率25. 31%. 其中單一感染檢齣476例,感染率18. 01%;兩種及以上亞型感染檢齣193例,感染率7. 30%;族彆統計958例,其中漢族暘性率24. 16%( 172/712 ) ,彝族暘性率29. 15%( 65/223 ) ,民族分析差異無統計學意義( =2. 24 P>0. 05 ). 檢齣23種HPV基因亞型,其中低危型暘性167例,以81型暘性最多;高危型暘性763例,暘性例數排前五位的為:52、16、58、53及18型. HPV暘性檢齣率以≤20歲( 38. 78%)及>51歲( 33. 21%)年齡段較高,感染檢齣率比較差異有統計學意義( =22. 99,P<0. 01). 結論 涼山地區女性宮頸HPV感染具有獨特的地域分佈和年齡分佈特點,族彆之間沒有差異.
목적 분석량산지구부녀궁경상피세포인유두류병독적감염정황급기주요형별. 방법 응용반향반점잡교-기인심편기술,대2014년1지8월취진적2643례녀성환자궁경탈락세포진행23충기인분형검측. 결과 2643빈표본검출양성669례,HPV감염솔25. 31%. 기중단일감염검출476례,감염솔18. 01%;량충급이상아형감염검출193례,감염솔7. 30%;족별통계958례,기중한족양성솔24. 16%( 172/712 ) ,이족양성솔29. 15%( 65/223 ) ,민족분석차이무통계학의의( =2. 24 P>0. 05 ). 검출23충HPV기인아형,기중저위형양성167례,이81형양성최다;고위형양성763례,양성례수배전오위적위:52、16、58、53급18형. HPV양성검출솔이≤20세( 38. 78%)급>51세( 33. 21%)년령단교고,감염검출솔비교차이유통계학의의( =22. 99,P<0. 01). 결론 량산지구녀성궁경HPV감염구유독특적지역분포화년령분포특점,족별지간몰유차이.
Objective To study infection situation and distribution of human papilloma virus( HPV) genotype from women with uterine cervical epithelial cells in Liangshan Area. Methods 2643 patients's uterine cervical cast-off cells from different age in January-August 2014 were detected and typed to 23 genotypes by dot blot hybridization reverse-gene chip. Results The posi-tive rate of HPV from 2643 patients was 25. 31%, about 699 patients;the single positive infection was 18. 01%, about 476 pa-tients;while the infection of two or more kinds of HPV subtypes was 7. 30%,about 193 patients. Statistics 958 cases depended on ethnicity. The positive rate of the Han people was 24. 16%(172/712),Yi people was 29. 15%(65/223),There was no significant difference in the national analysis. From 23 genotypes of HPV,the positive patients of low-risk types were 167,among them the 81 genotype was most;the positive rate of high-risk types were 763,the top five positive cases were 52 genotype、16 genotype、58 geno-type、53 genotype and 18 genotype. Moreover,the patients with positive HPV in the age group ≤20 years(38. 78%) and ≥ 51 years(33. 21%)were higher. Infection detection comparative difference was statistically significant( =22. 99 P<0. 01). Con-clusion Female uterine cervical HPV infection had a unique geographical and age distribution characteristics in Liangshan Area, There was no significant difference between ethnicity.
