四川医学
四川醫學
사천의학
Sichuan Medical Journal
2015年
10期
1470-1472
,共3页
马永能%彭秀娟%杨自力%刘国雄%刘姗%任皓月
馬永能%彭秀娟%楊自力%劉國雄%劉姍%任皓月
마영능%팽수연%양자력%류국웅%류산%임호월
卵巢癌%人附睾蛋白4%糖链抗原125%鉴别诊断
卵巢癌%人附睪蛋白4%糖鏈抗原125%鑒彆診斷
란소암%인부고단백4%당련항원125%감별진단
ovarian cancer%human epididymal protein 4%carbohydrate antigen 125%differential diagnosis
目的 比较人附睾蛋白4(HE4)和糖链抗原125(CA125)对卵巢癌和盆腔良性疾病鉴别诊断的临床价值.方法 用化学发光免疫分析法测定75例卵巢癌和80例盆腔良性疾病患者血清HE4和CA125水平. 结果 卵巢癌患者血清HE4和CA125水平显著高于盆腔良性疾病患者,差异有统计学意义( P <0. 05 ). 血清 HE4 对卵巢癌的灵敏度(SEN)、特异度(SPE)和准确度分别为70. 7%、91. 3%和81. 3%,血清 CA125 对卵巢癌的 SEN、SPE 和准确度分别为78. 7%、81. 3%和80. 0%,血清HE4+CA125并联试验对卵巢癌的SEN、SPE和准确度分别为88. 0%、78. 8%和83. 2%.HE4对Ⅰ期卵巢癌的灵敏度显著高于CA125,差异有统计学意义(P<0. 05). 结论 对卵巢癌和盆腔良性疾病的鉴别诊断,血清HE4优于CA125.
目的 比較人附睪蛋白4(HE4)和糖鏈抗原125(CA125)對卵巢癌和盆腔良性疾病鑒彆診斷的臨床價值.方法 用化學髮光免疫分析法測定75例卵巢癌和80例盆腔良性疾病患者血清HE4和CA125水平. 結果 卵巢癌患者血清HE4和CA125水平顯著高于盆腔良性疾病患者,差異有統計學意義( P <0. 05 ). 血清 HE4 對卵巢癌的靈敏度(SEN)、特異度(SPE)和準確度分彆為70. 7%、91. 3%和81. 3%,血清 CA125 對卵巢癌的 SEN、SPE 和準確度分彆為78. 7%、81. 3%和80. 0%,血清HE4+CA125併聯試驗對卵巢癌的SEN、SPE和準確度分彆為88. 0%、78. 8%和83. 2%.HE4對Ⅰ期卵巢癌的靈敏度顯著高于CA125,差異有統計學意義(P<0. 05). 結論 對卵巢癌和盆腔良性疾病的鑒彆診斷,血清HE4優于CA125.
목적 비교인부고단백4(HE4)화당련항원125(CA125)대란소암화분강량성질병감별진단적림상개치.방법 용화학발광면역분석법측정75례란소암화80례분강량성질병환자혈청HE4화CA125수평. 결과 란소암환자혈청HE4화CA125수평현저고우분강량성질병환자,차이유통계학의의( P <0. 05 ). 혈청 HE4 대란소암적령민도(SEN)、특이도(SPE)화준학도분별위70. 7%、91. 3%화81. 3%,혈청 CA125 대란소암적 SEN、SPE 화준학도분별위78. 7%、81. 3%화80. 0%,혈청HE4+CA125병련시험대란소암적SEN、SPE화준학도분별위88. 0%、78. 8%화83. 2%.HE4대Ⅰ기란소암적령민도현저고우CA125,차이유통계학의의(P<0. 05). 결론 대란소암화분강량성질병적감별진단,혈청HE4우우CA125.
Objective To compare the clinical values of serum human epididymal protein 4(HE4)and carbohydrate anti-gen 125(CA125)for differential diagnosis of ovarian cancer and benign pelvic disease. Methods The levels of serum HE4 and CA125 were measured in 75 patients with ovarian cancer and 80 patients with benign pelvic disease. Results The levels of HE4 and CA125 were significantly higher in patients with ovarian cancer than those in patients with benign pelvic diseases(P<0. 05). In comparison with patients with benign pelvic disease, the diagnosis sensitivity, specificity and accuracy of HE4 were 70. 7%, 91. 3% and 81. 3%, respectively. The diagnosis sensitivity, specificity and accuracy of CA125 were 78. 7%, 81. 3% and 80. 0%, respectively. The diagnosis sensitivity, specificity and accuracy of HE4/CA125 parallel detection were 88. 0%,78. 8% and 83. 2%,respectively. The diagnosis sensitivity of HE4 for ovarian cancer stageⅠwas significantly higher than that of CA125. Con-clusion For differentiation of benign and malignant pelvic mass,HE4 was a better marker than CA125.
