CAJ | 학술논문

炎性骨破坏和病理性骨化是强直性脊柱炎的特征性病理表现，有多种细胞因子和信号通路参与其中。目前，肿瘤坏死因子а、白细胞介素是最广为人知的参与炎性破坏的细胞因子，与此同时，伴随着越来越多新的生物学标志物的出现，Wnt／β－catenin信号通路、BMP／TGF－β信号通路等在AS骨化中的作用也日益受到重视。细胞因子介导的炎症与病理性骨化信号通路之间关系的研究，可能从分子水平上揭示强直性脊柱炎从炎症到骨化过程的机制，并为TNF抑制剂的长期临床应用提供依据。
염성골파배화병이성골화시강직성척주염적특정성병리표현，유다충세포인자화신호통로삼여기중。목전，종류배사인자а、백세포개소시최엄위인지적삼여염성파배적세포인자，여차동시，반수착월래월다신적생물학표지물적출현，Wnt／β－catenin신호통로、BMP／TGF－β신호통로등재AS골화중적작용야일익수도중시。세포인자개도적염증여병이성골화신호통로지간관계적연구，가능종분자수평상게시강직성척주염종염증도골화과정적궤제，병위TNF억제제적장기림상응용제공의거。
The pathological features of ankylosing spondylitis ( AS ) include inflammatory bone destruction and ectopic bone formation.Variety of cytokines and signaling pathways are involved in these two processes.At present, tumor necrosis factor-аand interleukins are most well-known inflammatory cytokines which lead to bone damage. Meanwhile, appearing of many new biomarkers, such as Wnt/β-catenin signaling pathway and BMP/TGF-βsignaling pathway, are attracting more and more attention. The study of the relationship between cytokines and signal pathways may reveal the mechanism of inflammation and pathological ossification in AS, which provides the evidence for the long-term use of anti-TNF drugs.