CAJ | 학술논문

维生素D是人体健康所必要的元素，它参与体内钙平衡及骨代谢。基质GLA蛋白（ matrix gla protein ，MGP）是一种维生素K依赖性蛋白，是人体内血管和软骨钙化的抑制剂，对骨形成有重要的影响。了解维生素D对MGP 表达的影响对探讨新的骨质疏松发病机理有着重要的意义。本文所述，维生素D与MGP这两种对骨形成有重要作用的影响因子之间存在着许多内在联系，维生素D除了能直接调节多种细胞MGP表达，也有可能通过调节钙磷代谢、雌二醇、维生素K2和BMP－2等多途径间接调节MGP表达，而且1，25（OH）2D3有可能通过激活Wnt／β－catenin信号通路调节MGP表达而影响骨形成。这和以往我们所了解的维生素D在骨代谢中的作用机制有所不同，
유생소D시인체건강소필요적원소，타삼여체내개평형급골대사。기질GLA단백（ matrix gla protein ，MGP）시일충유생소K의뢰성단백，시인체내혈관화연골개화적억제제，대골형성유중요적영향。료해유생소D대MGP 표체적영향대탐토신적골질소송발병궤리유착중요적의의。본문소술，유생소D여MGP저량충대골형성유중요작용적영향인자지간존재착허다내재련계，유생소D제료능직접조절다충세포MGP표체，야유가능통과조절개린대사、자이순、유생소K2화BMP－2등다도경간접조절MGP표체，이차1，25（OH）2D3유가능통과격활Wnt／β－catenin신호통로조절MGP표체이영향골형성。저화이왕아문소료해적유생소D재골대사중적작용궤제유소불동，
Vitamin D is an essential element involving in the calcium balance and bone metabolism.Matrix Gla protein is a vitamin K-dependent protein.It plays an important role in bone formation.It is important to understand the effect of vitamin D on the expression of MGP and to explore a new mechanism on osteoporosis.This paper reviews the connection of the two important influencing factors vitamin D and MGP.Besides the direct regulation of cellular MGP expression, vitamin D indirectly regulates MGP expression through the regulation of the metabolism of calcium and phosphors, estradiol, vitamin K2, and BMP2.Moreover, 1,25(OH)2D3 may regulate MGP expression and bone formation by activating Wnt/β-catenin signal pathway.It is different from our previous knowledge of the function of vitamin D in bone metabolism.