CAJ | 학술논문

目的：探讨乳腺癌组织中抗凋亡蛋白 Bcl-2的表达及其意义。方法：应用免疫组化方法检测124例乳腺癌组织中蛋白 Bcl-2的表达水平，分析其与各临床病理指标及与乳腺癌分子分型的关系，探讨其在预测乳腺癌预后中的价值。结果：Bcl-2的表达与 ER、PR 呈正相关，与肿瘤直径、组织学分级、临床分期、脉管癌栓等不良预后因素呈负相关；Bcl-2在绝经前女性低表达，在 Luminal 型乳腺癌中高表达，当 Bcl-2高表达时患者术后复发转移率低。结论：Bcl-2高表达的乳腺癌患者具有更好的预后，对内分泌治疗敏感，为临床更准确的进行个体化治疗提供依据。
목적：탐토유선암조직중항조망단백 Bcl-2적표체급기의의。방법：응용면역조화방법검측124례유선암조직중단백 Bcl-2적표체수평，분석기여각림상병리지표급여유선암분자분형적관계，탐토기재예측유선암예후중적개치。결과：Bcl-2적표체여 ER、PR 정정상관，여종류직경、조직학분급、림상분기、맥관암전등불량예후인소정부상관；Bcl-2재절경전녀성저표체，재 Luminal 형유선암중고표체，당 Bcl-2고표체시환자술후복발전이솔저。결론：Bcl-2고표체적유선암환자구유경호적예후，대내분비치료민감，위림상경준학적진행개체화치료제공의거。
Aim:To investigate the expressions and significance of Bcl-2 in breast carcinoma.Meth-ods:The expression level of Bcl-2 protein and in breast cancer tissues from 124 patients was detected with the method of immunohistochemistry and the relationship between Bcl-2 and other clinicopathologic factors were analyzed,also the prognosis value of Bcl-2 was analyzed.Results:The expression of Bcl-2 in breast cancer was positive associated with ER and PR expression,but negative associated with tumor size、clinical stage、lymphovascular and histological grade;In Premenopausal women,Bcl-2 also shows low expression,but shows high expression in Luminal subtypes breast cancer;In all breast cancer,Bcl-2 positive expression have longer disease-free survival compare with Bcl-2 negative expression.Conclu-sion:When Bcl-2 shows positive expressed of breast cancer patients have a better prognosis.So detection of Bcl-2 can be used to predict the prognosis of patients and guide individualized treatment.