CAJ | 학술논문

骨质疏松动物模型，是研究骨质疏松病理和抗骨质疏松药物作用机理的重要依据。本文详细地论述了4种骨质疏松动物模型的特点及原理：即（1）激素干预型骨质疏松动物模型，包括去势骨质疏松模型、甲状旁腺切除诱发的骨质疏松模型、下丘脑垂体缺陷诱发的骨质疏松模型、糖皮质激素诱导的骨质疏松模型和布舍瑞林诱发的骨质疏松模型等；（2）废用型骨质疏松动物模型，包括单侧肢体废用性模型、悬吊模型、钢板或螺钉内固定未骨折的骨骼诱发的骨质疏松模型、套筒法诱导大鼠骨质疏松模型和石膏绷带固定诱导骨质疏松模型等；（3）营养型骨质疏松模型，包括低钙饮食诱发的骨质疏松动物模型、低钠诱导的骨质疏松模型；（4）其它类型骨质疏松动物模型，包括维甲酸诱发的骨质疏松模型、链脲佐菌素诱发的骨质疏松模型、基因工程法诱导和联合造模法诱发的骨质疏松模型等。骨质疏松模型常见的评价包括密度测定法、生物化学指标法、骨形态学法和生物力学法等。衡量一种模型成功与否，必须将4种不同的指标评价方法结合起来进行综合评价，才能为基础和临床研究提供坚实的科学依据。
골질소송동물모형，시연구골질소송병리화항골질소송약물작용궤리적중요의거。본문상세지논술료4충골질소송동물모형적특점급원리：즉（1）격소간예형골질소송동물모형，포괄거세골질소송모형、갑상방선절제유발적골질소송모형、하구뇌수체결함유발적골질소송모형、당피질격소유도적골질소송모형화포사서림유발적골질소송모형등；（2）폐용형골질소송동물모형，포괄단측지체폐용성모형、현조모형、강판혹라정내고정미골절적골격유발적골질소송모형、투통법유도대서골질소송모형화석고붕대고정유도골질소송모형등；（3）영양형골질소송모형，포괄저개음식유발적골질소송동물모형、저납유도적골질소송모형；（4）기타류형골질소송동물모형，포괄유갑산유발적골질소송모형、련뇨좌균소유발적골질소송모형、기인공정법유도화연합조모법유발적골질소송모형등。골질소송모형상견적평개포괄밀도측정법、생물화학지표법、골형태학법화생물역학법등。형량일충모형성공여부，필수장4충불동적지표평개방법결합기래진행종합평개，재능위기출화림상연구제공견실적과학의거。
Osteoporotic animal models are the essential tools to study of the pathogenesis of osteoporosis and the pharmacology of osteoporosis drugs.This paper, in detail, discusses 4 types of osteoporotic animal models: ( 1 ) hormone intervention-induced osteoporosis animal models, including castrated animal model, parathyroidectomy animal mode, hypothalamic-pituitary defect-induced animal model, glucocorticoid-induced animal model, and buserelin-induced animal model; ( 2 ) immobilization-induced osteoporosis animal models, including unilateral limb disuse osteoporosis model, suspension-induced osteoporosis model, limb internal fixation with plate or screw-induced osteoporosis model, steel pipe fixation-induced animal model, and plaster bandage-induced osteoporosis model;(3) dietary intervention-induced osteoporosis models, including low calcium diet-induced osteoporosis model and low sodium diet-induced osteoporosis model; ( 4 ) other types of osteoporosis models, including retinoid-induced osteoporosis model, streptozotocin-induced osteoporosis model, gene engineer-induced osteoporosis model, and combined approaches-induced osteoporosis model.The evaluation methods for osteoporosis include the densitometry, biochemistry index, mechanical strength, and bone histomorphormetry. To judge whether the animal models is successful or not, we need to comprehensively consider the 4 evaluating indexes, in order to provide a solid base and scientific evidence for preclinical and clinical research.