CAJ | 학술논문

随着世界人口老年化比例不断上升，越来越多的人出现因骨质疏松引发的临床并发症如：骨质疏松性骨折、慢性骨痛、肌无力等。为了能够对骨质疏松症的发病机理及其治疗方法进行深入的研究，骨质疏松模型的建立是其的必备条件。目前已有多种方法建立骨质疏松模型，主要分为两大类，一类是体内模型，此类造模方法主要是以物理、化学或生物等致因素作用于动物，造成活体动物组织、器官或全身损害，并出现类似人类疾病时的功能、代谢或形态结构方面的改变。目前运用此法的主要有手术模型、药物去势模型、维甲酸模型、失用模型、营养模型、脑源性模型、基因重组模型等。另一类是体外模型，包括：盐酸模型、双氧水模型、细胞模型和计算机三维有限元模型。相比较体内模型来说，体外模型的研究范围较窄，只是在某些方面与人体骨质疏松具有相似之处。目前为止任何一种模型只是在某些方面与人体骨质疏松具有相似之处，没有任何一种模型在各个方面完全与人类骨质疏松症的临床表现一致。本文对骨质疏松模型建立方法研究进展及特点的进行阐述。
수착세계인구노년화비례불단상승，월래월다적인출현인골질소송인발적림상병발증여：골질소송성골절、만성골통、기무력등。위료능구대골질소송증적발병궤리급기치료방법진행심입적연구，골질소송모형적건립시기적필비조건。목전이유다충방법건립골질소송모형，주요분위량대류，일류시체내모형，차류조모방법주요시이물리、화학혹생물등치인소작용우동물，조성활체동물조직、기관혹전신손해，병출현유사인류질병시적공능、대사혹형태결구방면적개변。목전운용차법적주요유수술모형、약물거세모형、유갑산모형、실용모형、영양모형、뇌원성모형、기인중조모형등。령일류시체외모형，포괄：염산모형、쌍양수모형、세포모형화계산궤삼유유한원모형。상비교체내모형래설，체외모형적연구범위교착，지시재모사방면여인체골질소송구유상사지처。목전위지임하일충모형지시재모사방면여인체골질소송구유상사지처，몰유임하일충모형재각개방면완전여인류골질소송증적림상표현일치。본문대골질소송모형건립방법연구진전급특점적진행천술。
With the rising of the aging population in the world, more and more people suffers from clinical complications due to osteoporosis, such as osteoporotic fractures, chronic bone pain, muscle weakness, etc.In order to explore the pathogenesis of osteoporosis and its treatment methods, the establishment of the models of osteoporosis is essential.Now there are a variety of methods to establish the model of osteoporosis.It is mainly divided into two categories.One is the in vivo model.The in vivo method is mainly based on physical, chemical or biological pathogenic factors acting on the animals, resulting in the damage of tissue, organ, or the whole body in living animals, which is similar to the changes of metabolic function or morphology in human diseases.These method includes operation model, medical castration model, retinoic acid method, disuse model, nutrition model, brain derived model, gene recombination model, etc.The other one is the in vitro model, including: hydrochloric acid model, hydrogen peroxide model, cell model, and computer model of three-dimensional finite element.Comparing with the in vivo models, the study scope of the in vitro models is narrow.And it is similar to human osteoporosis in some areas only.So far every model is similar to human osteoporosis in certain extent.No model is entirely accordant with human osteoporosis in the clinical manifestation. This paper reviews the research progress and characteristics of the establishment of the osteoporotic models.