CAJ | 학술논문

目的：：观察文拉法辛缓释片联合喹硫平片治疗老年抑郁症患者的疗效及安全性。方法：将64例老年抑郁症患者分为研究组和对照组，每组各32例。两组患者均给予文拉法辛缓释片，研究组患者在此基础上增加喹硫平，疗程均为8周，比较两组患者治疗前及治疗后的HAMD-24评定疗效和TESS评定不良药物反应。结果：两组患者治疗后HAMD评分与治疗前比均降低(P<0.01)；研究组患者显效率高于对照组(P<0.05)；两组患者不良反应无显著差异。结论：文拉法辛联合喹硫平治疗老年抑郁症患者的疗效优于单纯喹硫平。
목적：：관찰문랍법신완석편연합규류평편치료노년억욱증환자적료효급안전성。방법：장64례노년억욱증환자분위연구조화대조조，매조각32례。량조환자균급여문랍법신완석편，연구조환자재차기출상증가규류평，료정균위8주，비교량조환자치료전급치료후적HAMD-24평정료효화TESS평정불량약물반응。결과：량조환자치료후HAMD평분여치료전비균강저(P<0.01)；연구조환자현효솔고우대조조(P<0.05)；량조환자불량반응무현저차이。결론：문랍법신연합규류평치료노년억욱증환자적료효우우단순규류평。
Objective:To explore efficacy and safety of the Venlafaxine hydrochloride sustained-release tablets combined with Quetiapine fumarate tablets in treatment of senile depression. Methods:64 senile depression patients were divided into study group ( n=32) and control group (n=32). The two groups were treated with Venlafaxine hydrochloride sustained-release tablets, while the study group were given Quetiapine fumarate tablets additionally. They were treated for 8 weeks. The efficacy and adverse drug reactions were evaluated with HAMD-24 and TESS, respectively. Results: The HAMD scores of the two groups were all decreased after the treatment (P<0. 01). The obvious effective rate of study group was higher than that of control group (P<0. 05). There was no statisti-cal significance in the adverse reaction between the two groups. Conclusions:A combination of Venlafaxine hydrochloride sustained-release tablets and Quetiapine fumarate tablets in the treatment of senile depression has superior effects than single Quetiapine fumarate tablets.