CAJ | 학술논문

目的：：探讨首发和长期住院精神分裂症患者的甲状腺素功能差异。方法：将226例精神分裂症患者分为首发组(106例)和长期住院组(120例)。另外选择62例正常人作为对照组。分别抽取3组研究对象的血液，检测FT3、FT4、T3、T4、TSH。结果：治疗前患者：FT3、FT4、T3长期住院组、首发组患者低于正常对照组(P均<0.05)，长期住院组患者的T4低于首发组、正常对照组(P均<0.05)；首发组患者的TSH低于长期住院组、正常对照组(P均<0.05)。治疗后患者：FT3、FT4、T3、T4对照组患者>长期住院组>首发组(P<0.05)；首发组患者的TSH低于长期住院组、正常对照组(P<0.05)。结论：未经治疗的首发精神分裂症患者甲状腺素水平降低；抗精神病药的使用后，甲状腺素水平逐渐降低。从长期住院精神分裂症患者看，随着病情的稳定，甲状腺素水平逐渐升高。
목적：：탐토수발화장기주원정신분렬증환자적갑상선소공능차이。방법：장226례정신분렬증환자분위수발조(106례)화장기주원조(120례)。령외선택62례정상인작위대조조。분별추취3조연구대상적혈액，검측FT3、FT4、T3、T4、TSH。결과：치료전환자：FT3、FT4、T3장기주원조、수발조환자저우정상대조조(P균<0.05)，장기주원조환자적T4저우수발조、정상대조조(P균<0.05)；수발조환자적TSH저우장기주원조、정상대조조(P균<0.05)。치료후환자：FT3、FT4、T3、T4대조조환자>장기주원조>수발조(P<0.05)；수발조환자적TSH저우장기주원조、정상대조조(P<0.05)。결론：미경치료적수발정신분렬증환자갑상선소수평강저；항정신병약적사용후，갑상선소수평축점강저。종장기주원정신분렬증환자간，수착병정적은정，갑상선소수평축점승고。
Objective:To discuss difference of thyroid hormone functions of first-episode and long-term hospitalized schizo-phrenics. Methods:(1) 106 first-episode schizophrenics, 120 long-term schizophrenics and 62 normal persons were divided into first-episode group, long-term hospitalized group and control group. The levels of FT3, FT4, T3, T4, TSH were detected. Results:Before the treatment:the levels of FT3, FT4, and T3 of long-term hospitalized group, first-episode group were lower than those of normal control group (P<0. 05); the level of T4 of long-term hospitalized group was lower than those of the other two groups (P<0. 05);and the level of TSH of first-episode group was lower than those of the other two groups (P<0. 05). After the treatment:for the levels of FT3, FT4, T3, and T4, control group>long-term hospitalized group>fist-episode group (P<0. 05);and for the level of TSH, first-episode group was lower than those of the other two groups (P<0. 05). Conclusions:Before the treatment, first-episode schizophrenics have a low level of thyroid hormones. Through action of antipsychotic drug, the levels of thyroid hormones decrease. To long-term hospitalized schizophrenics, with the stable of disease, the levels of thyroid hormones increase.