药学与临床研究
藥學與臨床研究
약학여림상연구
Pharmaceutical and Clinical Research
2015年
5期
494-496
,共3页
热毒宁注射液%浓度%急性上呼吸道感染%疗效%安全性
熱毒寧註射液%濃度%急性上呼吸道感染%療效%安全性
열독저주사액%농도%급성상호흡도감염%료효%안전성
Reduning injection%Concentrations%Acute upper respiratory tract infection%Efficacy%Safety
目的：考察热毒宁注射液不同稀释浓度治疗儿童急性上呼吸道感染的疗效与安全性。方法：采用回顾性调查分析的方法，对120例使用热毒宁注射液治疗的急性上呼吸道感染患儿，按热毒宁的不同稀释浓度（药液用量∶溶媒量）分为＞1∶4组（高浓度组）、1∶4～1∶20组（中浓度组）和＜1∶20组（低浓度组），观察3组患儿的疗效和安全性。结果与结论：高、中浓度两组患儿症状和体征恢复时间相当，但疗程均显著短于低浓度组（P＜0.05）；高、中浓度两组总有效率分别为94.59%和91.80%，差异无统计学意义（P＞0.05），但均显著高于低浓度组的63.64%（P＜0.05）；中、低浓度组不良反应发生率分别为4.92%和4.55%，差异无统计学意义（P＞0.05），但均显著低于高浓度组的16.22%（P＜0.05）。热毒宁注射液不同稀释浓度对治疗儿童急性上呼吸道感染的疗效和安全性均有影响，适当稀释（药液用量∶溶媒量为1∶4~1∶20）不仅具有良好的临床疗效，而且安全性也高。
目的：攷察熱毒寧註射液不同稀釋濃度治療兒童急性上呼吸道感染的療效與安全性。方法：採用迴顧性調查分析的方法，對120例使用熱毒寧註射液治療的急性上呼吸道感染患兒，按熱毒寧的不同稀釋濃度（藥液用量∶溶媒量）分為＞1∶4組（高濃度組）、1∶4～1∶20組（中濃度組）和＜1∶20組（低濃度組），觀察3組患兒的療效和安全性。結果與結論：高、中濃度兩組患兒癥狀和體徵恢複時間相噹，但療程均顯著短于低濃度組（P＜0.05）；高、中濃度兩組總有效率分彆為94.59%和91.80%，差異無統計學意義（P＞0.05），但均顯著高于低濃度組的63.64%（P＜0.05）；中、低濃度組不良反應髮生率分彆為4.92%和4.55%，差異無統計學意義（P＞0.05），但均顯著低于高濃度組的16.22%（P＜0.05）。熱毒寧註射液不同稀釋濃度對治療兒童急性上呼吸道感染的療效和安全性均有影響，適噹稀釋（藥液用量∶溶媒量為1∶4~1∶20）不僅具有良好的臨床療效，而且安全性也高。
목적：고찰열독저주사액불동희석농도치료인동급성상호흡도감염적료효여안전성。방법：채용회고성조사분석적방법，대120례사용열독저주사액치료적급성상호흡도감염환인，안열독저적불동희석농도（약액용량∶용매량）분위＞1∶4조（고농도조）、1∶4～1∶20조（중농도조）화＜1∶20조（저농도조），관찰3조환인적료효화안전성。결과여결론：고、중농도량조환인증상화체정회복시간상당，단료정균현저단우저농도조（P＜0.05）；고、중농도량조총유효솔분별위94.59%화91.80%，차이무통계학의의（P＞0.05），단균현저고우저농도조적63.64%（P＜0.05）；중、저농도조불량반응발생솔분별위4.92%화4.55%，차이무통계학의의（P＞0.05），단균현저저우고농도조적16.22%（P＜0.05）。열독저주사액불동희석농도대치료인동급성상호흡도감염적료효화안전성균유영향，괄당희석（약액용량∶용매량위1∶4~1∶20）불부구유량호적림상료효，이차안전성야고。
Objective: To investigate the efficacy and safety of different concentration of Reduning injection for children with acute upper respiratory tract infection (AURTI). Methods: Retrospective analysis was used in the study, 120 children with AURTI who were treated by Reduning injections were grouped into three groups by different solutions concentrations of Reduning injections, that were the >1∶4 (liquid amount: solvent amount) group (High-concentration group), 1∶20-1∶4 group (Moderate-concentration group) and <1∶20 group (Low-concentration group). The efficacy and safety was observed. Results & Conclusion:Recovery time of signs and symptoms of High- and Moderate-concentration groups were roughly the same, but significantly shorter than that of Low-concentration group (P<0.05); Total effective rates of High- and Moderate-concentration groups were 94.59% and 91.80% respectively, the difference between the two groups was not statistically significant (P>0.05), but they were significantly higher than that of Low-concentration group (63.64%) (P<0.05); Incidence of adverse reactions of Moderate- and Low-concentration groups were 4.92% and 4.55% respectively, the difference between the two groups was not statistically significant (P>0.05), but they were significantly lower than that of High-concentration group (16.22%) (P<0.05). Different solutions concentrations of Reduning injections have some impact on the efficacy and safety for AURTI, appropriate dilution has not only good clinical efficacy, but also high safety.
