药学与临床研究
藥學與臨床研究
약학여림상연구
Pharmaceutical and Clinical Research
2015年
5期
475-478
,共4页
华法林%基因多态性%给药模型%个体化用药%研究进展
華法林%基因多態性%給藥模型%箇體化用藥%研究進展
화법림%기인다태성%급약모형%개체화용약%연구진전
Warfarin%Gene polymorphism%Algorithm%Individualized medication%Research progress
华法林是临床广泛使用的抗凝药，但其疗效存在明显个体差异，其中基因多态性是导致华法林剂量差异主要影响因素。本文查阅相关文献，综述与华法林剂量相关的基因，为临床华法林个体化应用提供参考。
華法林是臨床廣汎使用的抗凝藥，但其療效存在明顯箇體差異，其中基因多態性是導緻華法林劑量差異主要影響因素。本文查閱相關文獻，綜述與華法林劑量相關的基因，為臨床華法林箇體化應用提供參攷。
화법림시림상엄범사용적항응약，단기료효존재명현개체차이，기중기인다태성시도치화법림제량차이주요영향인소。본문사열상관문헌，종술여화법림제량상관적기인，위림상화법림개체화응용제공삼고。
Warfarin is one of the most frequently prescribed anticoagulant and there is significant indi-vidual variability in dose requirement for the clinical effect. Gene polymorphisms are the important factors that can influence the anticoagulant effect of warfain. Recently, warfarin gene polymorphisms become a re-search topic and a large number of individualized medication algorithms have been established. This article reviews warfarin dosage related gene polymorphisms in order to offer some suggestions for warfarin individ-ualized medication.
