CAJ | 학술논문

目的：探讨受体酪氨酸激酶EphA1在肾细胞癌( renal cell carcinomas, RCC)中的表达,并分析其表达与临床病理特征的关系。方法采用免疫组化法检测144例肾透明细胞癌、18例肾嫌色细胞癌和6例肾乳头状癌组织中EphA1蛋白的表达,并复习相关文献。结果 EphA1在正常肾小管中高表达。 EphA1蛋白在64．6%(93/144)肾透明细胞癌中呈阴性或弱阳性,35．4%(51/144)呈阳性。 EphA1蛋白在肾嫌色细胞癌和乳头状癌中均呈阳性。 EphA1蛋白高表达与肾透明细胞癌患者年龄(P<0．001)、性别(P=0．016)以及核级(P<0．001)有关,与肿瘤直径无关(P=0．316)。结论 EphA1蛋白有可能成为肾透明细胞癌临床预后的新标志物。
목적：탐토수체락안산격매EphA1재신세포암( renal cell carcinomas, RCC)중적표체,병분석기표체여림상병리특정적관계。방법채용면역조화법검측144례신투명세포암、18례신혐색세포암화6례신유두상암조직중EphA1단백적표체,병복습상관문헌。결과 EphA1재정상신소관중고표체。 EphA1단백재64．6%(93/144)신투명세포암중정음성혹약양성,35．4%(51/144)정양성。 EphA1단백재신혐색세포암화유두상암중균정양성。 EphA1단백고표체여신투명세포암환자년령(P<0．001)、성별(P=0．016)이급핵급(P<0．001)유관,여종류직경무관(P=0．316)。결론 EphA1단백유가능성위신투명세포암림상예후적신표지물。
Purpose To investigate the expression of EphA1 in renal cell carcinomas ( RCC) and to analyze its correlation with clini-copathological parameters in order to explore the clinical significance of EphA1 protein in renal cell carcinomas ( RCC) . Methods The immunocytochemical method was employed to measure the expression of EphA1 in 144 clear cell RCC ( ccRCC) tissues, 18 chro-mophobe RCC tissues and 6 papillary RCC tissues. Correlation between EphA1 protein expression and clinical parameters was evaluated by statistics. Results High level of the expression of EphA1 was observed in all normal renal tubes. The EphA1 protein was negative-ly or weakly expressed in 93 out of 144 ccRCC (64. 6%) and positively expressed in 51 out of 144 ccRCC (35. 4%). Positive expres-sion of EphA1 was observed in all samples of chromophobe RCC and papillary RCC. The high level expression of the EphA1 protein was significantly associated with younger patients (P<0. 001), sex (P=0. 016) and lower nuclear grade (P<0. 001). No significant relation between the expression of EphA1 and tumor diameter was found ( P=0. 316 ) . Conclusion EphA1 protein may be a new marker for the prognosis of ccRCC.