CAJ | 학술논문

目的：探讨在2型糖尿病患者中血清戊糖素水平与骨转换指标之间的相关性以了解戊糖素对骨代谢的影响。方法190例绝经后女性及＞60岁男性2型糖尿病患者于空腹状态下抽取空腹静脉血液查肝肾功能、糖化血红蛋白（ HbA1 C ）、I型胶原羧基端肽β特殊序列（β?CTX）、I型前胶原氨基端前肽（ PINP）、骨钙素（ OC）及戊糖素水平，分析戊糖素与肝肾功能及骨转换指标之间的相关性。结果相关分析结果提示戊糖素与糖尿病病程、HbA1c、β?CTX水平相关（ r＝0?492、0?158和－0?156， P均＜0?05），而与PINP及OC之间的相关性无统计学意义（P＝0?646和0?72）。多元线性回归分析结果提示戊糖素水平与糖尿病病程、HbA1C相关（P均＜0?05），而与β?CTX的相关性无统计学意义（P＝0?199）。结论2型糖尿病患者血戊糖素水平与骨转换指标PINP、β?CTX及OC水平之间无明显的相关性。
목적：탐토재2형당뇨병환자중혈청무당소수평여골전환지표지간적상관성이료해무당소대골대사적영향。방법190례절경후녀성급＞60세남성2형당뇨병환자우공복상태하추취공복정맥혈액사간신공능、당화혈홍단백（ HbA1 C ）、I형효원최기단태β특수서렬（β?CTX）、I형전효원안기단전태（ PINP）、골개소（ OC）급무당소수평，분석무당소여간신공능급골전환지표지간적상관성。결과상관분석결과제시무당소여당뇨병병정、HbA1c、β?CTX수평상관（ r＝0?492、0?158화－0?156， P균＜0?05），이여PINP급OC지간적상관성무통계학의의（P＝0?646화0?72）。다원선성회귀분석결과제시무당소수평여당뇨병병정、HbA1C상관（P균＜0?05），이여β?CTX적상관성무통계학의의（P＝0?199）。결론2형당뇨병환자혈무당소수평여골전환지표PINP、β?CTX급OC수평지간무명현적상관성。
Objective To investigate the relationship between serum pentosidine and boner turnover markers in patients with type 2 diabetes mellitus (T2DM). Methods One hundred and ninety postmenopausal women and over 60 years old men with T2DM were enrolled. Fasting blood was withdrawn. The hemoglobin A1c (HbA1C), C?terminal telopeptide of type I collagen (β?CTX), N?terminal propeptides of type I procollagen ( PINP) , osteocalcin ( OC) , and serum pentosidine were determined. The relationship between pentosidine and liver and kidney function and bone turn markers was analyzed. Results The serum penotosidine levels were positively correlated with the duration of T2DM (r=0?492, P<0?05) and HbA1c (r=0?158, P<0?05), but negatively correlated with β?CTX (r= -0?156, P<0?05). Multiple linear regression analysis showed that the duration of the T2DM and HbA1c were associated with the serum pentosidine levels but were not associated with β?CTX. Conclusion The serum penotosidine level is not related to bone turnover markers in T2DM patients.