CAJ | 학술논문

目的：探讨孕妇血清同型半胱氨酸（Hcy）浓度升高对胎儿的影响．方法：前瞻性研究176名孕妇早期的血清 Hcy 浓度及其围产儿关系，用循环酶法测量孕妇妊娠早期的血清 Hcy 浓度，以正常孕妇血清 Hcy 浓度的第75个百分位（P75）为界，分为高 Hcy 浓度组和正常 Hcy 浓度组，分析 Hcy 浓度与胎儿不良结局的关系．结果：妊娠早期血清 Hcy 浓度＞7.53μmol／L，胎儿发生先天畸形、胎儿生长迟缓（FGR）的风险分别增加6.77（95％ CI：1.41，32.52；P ＜0.05）和4.52（1.42，14.35；P ＜0.05）倍．结论：妊娠早期血清 Hcy 浓度升高是胎儿发生先天畸形、FGR危险因素．
목적：탐토잉부혈청동형반광안산（Hcy）농도승고대태인적영향．방법：전첨성연구176명잉부조기적혈청 Hcy 농도급기위산인관계，용순배매법측량잉부임신조기적혈청 Hcy 농도，이정상잉부혈청 Hcy 농도적제75개백분위（P75）위계，분위고 Hcy 농도조화정상 Hcy 농도조，분석 Hcy 농도여태인불량결국적관계．결과：임신조기혈청 Hcy 농도＞7.53μmol／L，태인발생선천기형、태인생장지완（FGR）적풍험분별증가6.77（95％ CI：1.41，32.52；P ＜0.05）화4.52（1.42，14.35；P ＜0.05）배．결론：임신조기혈청 Hcy 농도승고시태인발생선천기형、FGR위험인소．
Aim:Increased homocysteine has been reported to be associated with pregnancy outcome. The present study was designed prospectively to explore the effect of maternal homocysteine (Hcy)level on the fetus.Methods:This study included 176 pregnant women and their offspring.Maternal serum ho-mocysteine was measured in the first trimester of pregnancy by using enzymatic cycling assay.The mater-nal data and the pregnancy outcome were recorded.Results:Mothers with high serum Hcy levels at the first trimester of pregnancy were seven times [relative risk ratio,6.77 (95% confidence interval,1.41, 32.52);P <0.05]more likely to give birth to a neonate with congenital abnormalities,and five times [4.52 (1.42,14.35);P <0.05]with fetal growth retardation.Conclusion:Increased serum homocys-teine level in pregnant women was a risk factor for congenital abnormalities and fetal growth retardation.