CAJ | 학술논문

女性绝经后体内雌激素水平下降可导致骨质疏松。近年来有学者发现，除了雌激素通过调节钙离子水平在骨代谢过程中发挥重要作用外，镁离子也有可能会影响骨质的形成与吸收。血清镁及雌激素相互作用改变了骨质的钙含量，即二者与女性绝经后骨质疏松存在一定关联，但两者之间的具体关系却并不十分明确。众多试验结果表明，相对于单独一种镁离子或钙离子含量对骨质疏松发生率的影响，在女性绝经后体内雌激素水平低下的情况下，镁／钙离子的含量比显得更为重要。研究显示，血清镁离子含量过高或者过低都可能会引起钙离子代谢异常，可能导致两种离子的浓度比失衡，进而对骨代谢产生不利影响，增加女性绝经后患骨质疏松的风险。因此维持绝经后体内镁／钙平衡有利于维持骨组织代谢的稳定，同时为治疗骨质疏松提供线索。即不能单纯的强调补充镁离子或者钙离子，而是应该根据患者血清中钙镁离子的具体浓度和比例来制定治疗方案。
녀성절경후체내자격소수평하강가도치골질소송。근년래유학자발현，제료자격소통과조절개리자수평재골대사과정중발휘중요작용외，미리자야유가능회영향골질적형성여흡수。혈청미급자격소상호작용개변료골질적개함량，즉이자여녀성절경후골질소송존재일정관련，단량자지간적구체관계각병불십분명학。음다시험결과표명，상대우단독일충미리자혹개리자함량대골질소송발생솔적영향，재녀성절경후체내자격소수평저하적정황하，미／개리자적함량비현득경위중요。연구현시，혈청미리자함량과고혹자과저도가능회인기개리자대사이상，가능도치량충리자적농도비실형，진이대골대사산생불리영향，증가녀성절경후환골질소송적풍험。인차유지절경후체내미／개평형유리우유지골조직대사적은정，동시위치료골질소송제공선색。즉불능단순적강조보충미리자혹자개리자，이시응해근거환자혈청중개미리자적구체농도화비례래제정치료방안。
The descent of estrogen level during postmenopausal period may cause osteoporosis. For the past several years, some scholars have found that similar to the estrogen, magnesium also plays an important role in bone formation as well as bone resorption. Estrogen and serum magnesium may interact with each other to impact the calcium level in bone, thus impact on postmenopausal osteoporosis. The correlation between them is not clear. Most experiments indicate that the ratio of calcium and magnesium ion is much more important than that of either of them when low level of estrogen occurs in postmenopausal women. Too high or low level of magnesium may cause abnormal calcium metabolism and imbalance of the two ions, and it may increase the risk of osteoporosis in postmenopausal women. So maintaining the balance between calcium and magnesium ion is in favor of maintaining the stability bone metabolism. It gives us clues to the treatment of osteoporosis. The treatment of osteoporosis should base on the ratio of serum magnesium and calcium, but not either of them only.