中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
Chinese Journal of Clinicians (Electronic Edition)
2015年
19期
3508-3511
,共4页
结直肠肿瘤%危险因素%糖尿病
結直腸腫瘤%危險因素%糖尿病
결직장종류%위험인소%당뇨병
Colorectal neoplasms%Risk factors%Diabetes mellitus
目的：研究糖尿病与结直肠癌相关关系，为结直肠癌病因学探讨及预防筛查提供依据。方法回顾性分析2013年3月至2015年3月在山西大医院、山西医科大学第一附属医院住院的，经病理科确诊，病例详细记载有检验数据、糖尿病史、糖尿病家族史、结直肠癌家族史312例结直肠癌患者为病例组，按匹配原则选择同时期住院的非结直肠癌患者423例作为对照组。采用Logistic回归分析方法研究结直肠癌是否与糖尿病有关联。记录并分析病例组中糖尿病患者的患病病程以及结直肠癌发病部位并进行统计学处理。结果 Logistic逐步回归分析方法显示糖尿病史、结直肠癌家族史是结直肠癌的独立危险因素。糖尿病病例组中＜5年、5～10年、10～20年、＞20年的OR值分别是2.869、3.130、3.228、1.267。糖尿病与结直肠癌发生的部位差异有统计学意义（P＜0.05）。结论（1）糖尿病增加了罹患结直肠癌的相对危险性，是结直肠癌发生的独立危险因素。（2）随着糖尿病病程的增加，结直肠癌的危险性增加，若病程超过20年，风险反而下降。（3）糖尿病引起结肠癌的患病风险增加，以右半结肠较为明显。
目的：研究糖尿病與結直腸癌相關關繫，為結直腸癌病因學探討及預防篩查提供依據。方法迴顧性分析2013年3月至2015年3月在山西大醫院、山西醫科大學第一附屬醫院住院的，經病理科確診，病例詳細記載有檢驗數據、糖尿病史、糖尿病傢族史、結直腸癌傢族史312例結直腸癌患者為病例組，按匹配原則選擇同時期住院的非結直腸癌患者423例作為對照組。採用Logistic迴歸分析方法研究結直腸癌是否與糖尿病有關聯。記錄併分析病例組中糖尿病患者的患病病程以及結直腸癌髮病部位併進行統計學處理。結果 Logistic逐步迴歸分析方法顯示糖尿病史、結直腸癌傢族史是結直腸癌的獨立危險因素。糖尿病病例組中＜5年、5～10年、10～20年、＞20年的OR值分彆是2.869、3.130、3.228、1.267。糖尿病與結直腸癌髮生的部位差異有統計學意義（P＜0.05）。結論（1）糖尿病增加瞭罹患結直腸癌的相對危險性，是結直腸癌髮生的獨立危險因素。（2）隨著糖尿病病程的增加，結直腸癌的危險性增加，若病程超過20年，風險反而下降。（3）糖尿病引起結腸癌的患病風險增加，以右半結腸較為明顯。
목적：연구당뇨병여결직장암상관관계，위결직장암병인학탐토급예방사사제공의거。방법회고성분석2013년3월지2015년3월재산서대의원、산서의과대학제일부속의원주원적，경병이과학진，병례상세기재유검험수거、당뇨병사、당뇨병가족사、결직장암가족사312례결직장암환자위병례조，안필배원칙선택동시기주원적비결직장암환자423례작위대조조。채용Logistic회귀분석방법연구결직장암시부여당뇨병유관련。기록병분석병례조중당뇨병환자적환병병정이급결직장암발병부위병진행통계학처리。결과 Logistic축보회귀분석방법현시당뇨병사、결직장암가족사시결직장암적독립위험인소。당뇨병병례조중＜5년、5～10년、10～20년、＞20년적OR치분별시2.869、3.130、3.228、1.267。당뇨병여결직장암발생적부위차이유통계학의의（P＜0.05）。결론（1）당뇨병증가료리환결직장암적상대위험성，시결직장암발생적독립위험인소。（2）수착당뇨병병정적증가，결직장암적위험성증가，약병정초과20년，풍험반이하강。（3）당뇨병인기결장암적환병풍험증가，이우반결장교위명현。
ObjectiveTo provid the basis for the etiology, prevention, and colorectal cancer screening by studying the correlation between diabetes and colorectal cancer.MethodsA retrospective analysis from March 2013 to March 2015 in Shanxi Dayi Hospital and First Affiliated Hospital of Shanxi Medical University. 312 patients were confirmed by pathology and consists of the case group. Results of testing, history of diabetes, family history of diabetes, and family history of colorectal cancer should be included in the medical records. Matching the principle of non-selection, 423 patients with colorectal cancer during the same period of hospitalization consists of the control group. Logistic regression was used to analysis the correlation between colorectal cancer and diabetes. Courses of diabetes and locations of colorectal cancer were recorded and analyzed with SPSS 19.0.ResultsLogistic regression analysis showed history of diabetes and family history of colorectal cancer were independent risk factors for colorectal cancer. Cases of diabetes group <5 years, 5 to 10 years,10 to 20 years, >20 yearsOR values were 2.869, 3.130, 3.228, 1.267. Diabetes and the locations of colorectal cancer were statistically significant (P<0.05).ConclusionDiabetes was a independent risk factor for colorectal cancer by increasing its risk of incidence. The risk of colorectal cancer increases with the increasing duration of diabetes over time, but risk decreased if the duration was over 20 years. Diabetes increases the risk of colon cancer, especially in the right hemicolon.
