CAJ | 학술논문

目的：探讨黑斑胃肠道息肉病（PJS）息肉病理性质与癌变的关系。方法本文采用回顾性研究，研究对象分为病例组与对照组。病例组为18例PJS患者的息肉组织；对照组为36例非PJS患者的息肉或癌组织。PJS患者中4例癌变患者、14例结肠镜检与复查患者的息肉组织，按大、中、小选择息肉组织做标本，并在其内、中、外部各取组织3块，共制作586个病理切片，与其他大肠癌及其他疾病的息肉组织比较，由院内两位病理专家进行单盲对比阅片，确定病理性质，并进行采用Kappa一致性分析和统计学检验。结果所检息肉均为腺瘤性质，癌变发生于腺瘤性息肉；经统计检验后结果显示PJS患者与其他大肠癌或其他肠息肉病理性质无差异。结论本组PJS病例肠息肉均为腺瘤性质，是该病大肠癌发生的根本原因；这很可能为PJS患者息肉癌变的另一途径，即：腺瘤-癌变的发展过程。
목적：탐토흑반위장도식육병（PJS）식육병이성질여암변적관계。방법본문채용회고성연구，연구대상분위병례조여대조조。병례조위18례PJS환자적식육조직；대조조위36례비PJS환자적식육혹암조직。PJS환자중4례암변환자、14례결장경검여복사환자적식육조직，안대、중、소선택식육조직주표본，병재기내、중、외부각취조직3괴，공제작586개병리절편，여기타대장암급기타질병적식육조직비교，유원내량위병리전가진행단맹대비열편，학정병이성질，병진행채용Kappa일치성분석화통계학검험。결과소검식육균위선류성질，암변발생우선류성식육；경통계검험후결과현시PJS환자여기타대장암혹기타장식육병이성질무차이。결론본조PJS병례장식육균위선류성질，시해병대장암발생적근본원인；저흔가능위PJS환자식육암변적령일도경，즉：선류-암변적발전과정。
Objective To discuss the relationship between the character of Peutz-Jeghers syndrome(PJS) polys and cancerization of polyps.MethodsAll pathological slices in groups were retrospectively reviewed. 18 cases of PJS were in case group, 36 cases of non-PJS in control group. According to the different sizes of resected malignant tissue of polys as samples from the different sections of them, 4 patients with cancerous polys and 14 patients with colonoscope were followed up. 586 pathological slices were cut. These pathological slices were compared with other types of colon cancer and polyps. These samples using single-blind method were diagnosed by two pathological experts in our and external hospitals to ensure their kinds of pathology. And then, diagnosed results were analyzed using statistical test.ResultsAll researched polyps were adenomatous. Cancerization occurs in the adenomatous polyps. It is not different with other types of colon polyps afterχ2 test.ConclusionAll the polyps were adenoma in this group patients. Adenomatous polyps occurs cancerization. It may be the other possible process of adenomatous polyps to cancerization in PJS.