中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
Chinese Journal of Clinicians (Electronic Edition)
2015年
19期
3485-3487
,共3页
药物性肝损伤%机制
藥物性肝損傷%機製
약물성간손상%궤제
Drug-induced liver injury%Mechanism
药物性肝损伤是指药物或其代谢产物引起的肝功能异常或肝脏对药物及代谢产物的超敏反应所致的疾病，分为本质性肝损伤和特异性肝损伤两大类，与细胞色素 P450（CYP450）酶系统相关的药物性肝损伤是特异性肝损伤发生最主要的机制，药物或其代谢产物的直接损伤、过敏反应、免疫系统激活和氧化应激造成线粒体损伤也是药物性肝损伤发生的主要因素之一。
藥物性肝損傷是指藥物或其代謝產物引起的肝功能異常或肝髒對藥物及代謝產物的超敏反應所緻的疾病，分為本質性肝損傷和特異性肝損傷兩大類，與細胞色素 P450（CYP450）酶繫統相關的藥物性肝損傷是特異性肝損傷髮生最主要的機製，藥物或其代謝產物的直接損傷、過敏反應、免疫繫統激活和氧化應激造成線粒體損傷也是藥物性肝損傷髮生的主要因素之一。
약물성간손상시지약물혹기대사산물인기적간공능이상혹간장대약물급대사산물적초민반응소치적질병，분위본질성간손상화특이성간손상량대류，여세포색소 P450（CYP450）매계통상관적약물성간손상시특이성간손상발생최주요적궤제，약물혹기대사산물적직접손상、과민반응、면역계통격활화양화응격조성선립체손상야시약물성간손상발생적주요인소지일。
Drug induced liver injury refers toliver function abnormalities caused by drugs or their metabolites or liver disease caused by hypersensitivity to the drug and their metabolites. It can be divided into the essence of liver injury and liver specific injury, mechanism of specific liver injury is the most important with cytochrome P450 (CYP450) of hepatic injury related enzyme system, direct injury of drugs and their metabolites, allergic reactions, immune system activation, mitochondrial damage caused by oxidative stress, all of these are one of the main causes of drug-induced liver injury.
