CAJ | 학술논문

目的：观察丙戊酸钠治疗早期疗效欠佳的首发精神分裂症患者的后期疗效。方法选取83例早期疗效欠佳的首发精神分裂症患者，随机分为继续单一用药即对照组（40例）与合并丙戊酸钠缓释片组即研究组（43例）。于治疗后第3、4周末进行阳性和阳性综合征量表（ PANSS）评定，采用治疗中需处理的不良反应症状量表（ TESS）评定患者的不良反应。结果研究组治疗后第3、4周末PANSS总分低于对照组（ P＜0．05），研究组治疗后第3、4周PANSS减分率高于对照组（P＜0．05）；研究组（90．70％）总有效率高于对照组（70．00％）（P＜0．05）；两组总不良反应发生率比较差异无统计学意义（P＞0．05）。结论抗精神病药物合并丙戊酸纳缓释片可提高早期疗效欠佳的首发精神分裂症患者的后期疗效，不良反应较小。
목적：관찰병무산납치료조기료효흠가적수발정신분렬증환자적후기료효。방법선취83례조기료효흠가적수발정신분렬증환자，수궤분위계속단일용약즉대조조（40례）여합병병무산납완석편조즉연구조（43례）。우치료후제3、4주말진행양성화양성종합정량표（ PANSS）평정，채용치료중수처리적불량반응증상량표（ TESS）평정환자적불량반응。결과연구조치료후제3、4주말PANSS총분저우대조조（ P＜0．05），연구조치료후제3、4주PANSS감분솔고우대조조（P＜0．05）；연구조（90．70％）총유효솔고우대조조（70．00％）（P＜0．05）；량조총불량반응발생솔비교차이무통계학의의（P＞0．05）。결론항정신병약물합병병무산납완석편가제고조기료효흠가적수발정신분렬증환자적후기료효，불량반응교소。
Objective To explore valproate zyban combined with antipsychotic for late curative effects in first-episode schizophrenic patients with poor early curative effects.Methods A total of 83 first-episode schizophrenic patients with poor early curative effects were randomly divided into study group (43 cases) treated with valproate zyban combined with antipsychotic and control group (40 cases) treated with mono-antipsychotic.They were assessed with the Positive and Negative Syndrome Scale (PANSS) and Treatment Emergent Symptoms Scale(TESS) at the 3rd and 4th weekend of treatment.Results At the 3rd and 4th weekend of treatment, the total scores of PANSS in study group were significantly lower than those in control group ( P<0.05) and the reduction rates of PANSS in study group were significantly higher than those in control group ( P <0.05).At 4th weekend of treatment, the total efficiency rate in study group was significantly higher than that in control group (P<0.05). There was no difference for total incidence of side effects between two groups ( P >0.05).Conclusion It’s effective for valproate zyban combined with antipsychotic for late curative effects in first-episode schizophrenic patients with poor early curative effects, and there are few side effects.