现代医药卫生
現代醫藥衛生
현대의약위생
Journal of Modern Medicine & Health
2015年
20期
3050-3052,3055
,共4页
宋典坤%关为群%王学莹%刘瑜佳
宋典坤%關為群%王學瑩%劉瑜佳
송전곤%관위군%왕학형%류유가
扁平苔癣,口腔%受体,细胞表面%脂氧素类%NF-κB%免疫组织化学
扁平苔癬,口腔%受體,細胞錶麵%脂氧素類%NF-κB%免疫組織化學
편평태선,구강%수체,세포표면%지양소류%NF-κB%면역조직화학
Lichen planus,oral%Receptors,cell surface%Lipoxins%NF-κB%Immunohistochemistry
目的：通过检测脂氧素A4受体（ALX-R）及核因子-κBp65（NF-κBp65）在口腔扁平苔藓（OLP）病灶黏膜中的表达情况，探讨二者在OLP发病机制中的可能作用。方法采用免疫组化法检测30例OLP组织（糜烂型OLP组16例，非糜烂型OLP组14例）与10例正常口腔黏膜组织（对照组）中ALX-R和NF-κBp65蛋白的表达情况。结果（1） ALX-R蛋白，在糜烂型与非糜烂型OLP组织中表达阳性率比较，差异无统计学意义（P>0.05）；OLP组织中，糜烂型组NF-κBp65蛋白表达阳性率高于非糜烂型组，差异有统计学意义（P<0.05）；（2）OLP组ALX-R蛋白表达阳性率低于对照组，NF-κBp65蛋白表达阳性率高于对照组，差异均有统计学意义（P<0.01）；（3）OLP组和对照组中ALX-R与NF-κBp65的蛋白表达均呈负相关（r=-1，P<0.01）。结论 ALX-R与NF-κBp65表达异常可能与OLP的发病机制密切相关。
目的：通過檢測脂氧素A4受體（ALX-R）及覈因子-κBp65（NF-κBp65）在口腔扁平苔蘚（OLP）病竈黏膜中的錶達情況，探討二者在OLP髮病機製中的可能作用。方法採用免疫組化法檢測30例OLP組織（糜爛型OLP組16例，非糜爛型OLP組14例）與10例正常口腔黏膜組織（對照組）中ALX-R和NF-κBp65蛋白的錶達情況。結果（1） ALX-R蛋白，在糜爛型與非糜爛型OLP組織中錶達暘性率比較，差異無統計學意義（P>0.05）；OLP組織中，糜爛型組NF-κBp65蛋白錶達暘性率高于非糜爛型組，差異有統計學意義（P<0.05）；（2）OLP組ALX-R蛋白錶達暘性率低于對照組，NF-κBp65蛋白錶達暘性率高于對照組，差異均有統計學意義（P<0.01）；（3）OLP組和對照組中ALX-R與NF-κBp65的蛋白錶達均呈負相關（r=-1，P<0.01）。結論 ALX-R與NF-κBp65錶達異常可能與OLP的髮病機製密切相關。
목적：통과검측지양소A4수체（ALX-R）급핵인자-κBp65（NF-κBp65）재구강편평태선（OLP）병조점막중적표체정황，탐토이자재OLP발병궤제중적가능작용。방법채용면역조화법검측30례OLP조직（미란형OLP조16례，비미란형OLP조14례）여10례정상구강점막조직（대조조）중ALX-R화NF-κBp65단백적표체정황。결과（1） ALX-R단백，재미란형여비미란형OLP조직중표체양성솔비교，차이무통계학의의（P>0.05）；OLP조직중，미란형조NF-κBp65단백표체양성솔고우비미란형조，차이유통계학의의（P<0.05）；（2）OLP조ALX-R단백표체양성솔저우대조조，NF-κBp65단백표체양성솔고우대조조，차이균유통계학의의（P<0.01）；（3）OLP조화대조조중ALX-R여NF-κBp65적단백표체균정부상관（r=-1，P<0.01）。결론 ALX-R여NF-κBp65표체이상가능여OLP적발병궤제밀절상관。
[Abstatct] Objective To detect the expression of lipoxin A4 receptor (ALX-R) and the transcription nuclear factorκBp65 (NF-κBp65) in oral mucosal lesion of the patients with oral lichen planus (OLP) and to investigate their possible roles in the patho-genesis of OLP. Methods Immunohistochemistry was adopted to detect the expression of ALX-R and NF-κBp65 protein in the oral mucosa of 30 OLP patients (including 16 cases of erosive type and 14 cases of non-erosive type) and 10 cases of normal oral mucosa(control group). Results (1)The positive rate of ALX-R protein expression had no statistical difference between the ero-sive type OLP tissue and the non-erosive type OLP tissue(P>0.05);in OLP oral mucosa tissue, the positive rate of NF-κBp65 pro-tein expression in the erosive type group was higher than that in the non-erosive type group,the difference was statistically signifi-cant(P<0.05);(2)the positive rate of ALX-R protein expression in the OLP group was lower than that in the control group(P<0.05), but the positive rate of NF-κBp65 protein expression in the OLP group was significantly higher than that in the control group ,the difference was statistically significant(P<0.01);(3)the ALX-R protein expression in the OLP group and the control group was negatively correlated with the NF-κBp65 protein expression=-1,P<0.01). Conclusion The abnormal expressions of ALX-R and NF-κBp65 in oral mucosa may be closely related with the pathogenesis of OLP.
