CAJ | 학술논문

目的：探讨脑电生物反馈治疗合并坦度螺酮治疗广泛性焦虑障碍的疗效。方法将120例广泛性焦虑障碍患者随机分为研究组和对照组各60例，研究组给予脑电生物反馈治疗合并坦度螺酮系统治疗，对照组仅接受坦度螺酮系统治疗，共计6周，于基线及治疗后第2、4、6周末分别采用汉密尔顿焦虑量表（ HAMA）、焦虑自评量表（ SAS）和治疗中需处理的不良反应症状量表（ TESS）评定疗效及不良反应。结果治疗后第2、4、6周末研究组HAMA、SAS评分均较基线下降（P＜0．05），对照组治疗后第4、6周末较基线下降（P＜0．05）。治疗后第2、4、6周末，研究组的HAMA、SAS评分均低于对照组（P＜0．05）。治疗后第6周末研究组临床有效率显著高于对照组（P＜0．05）。两组间不良反应发生率比较差异无统计学意义（ P＞0．05）。结论脑电生物反馈治疗合并坦度螺酮可有效、快速安全地治疗广泛性焦虑障碍。
목적：탐토뇌전생물반궤치료합병탄도라동치료엄범성초필장애적료효。방법장120례엄범성초필장애환자수궤분위연구조화대조조각60례，연구조급여뇌전생물반궤치료합병탄도라동계통치료，대조조부접수탄도라동계통치료，공계6주，우기선급치료후제2、4、6주말분별채용한밀이돈초필량표（ HAMA）、초필자평량표（ SAS）화치료중수처리적불량반응증상량표（ TESS）평정료효급불량반응。결과치료후제2、4、6주말연구조HAMA、SAS평분균교기선하강（P＜0．05），대조조치료후제4、6주말교기선하강（P＜0．05）。치료후제2、4、6주말，연구조적HAMA、SAS평분균저우대조조（P＜0．05）。치료후제6주말연구조림상유효솔현저고우대조조（P＜0．05）。량조간불량반응발생솔비교차이무통계학의의（ P＞0．05）。결론뇌전생물반궤치료합병탄도라동가유효、쾌속안전지치료엄범성초필장애。
Objective To explore the effectiveness of EEG-biofeedback therapy combined with tandospirone in treatment of patients with generalized anxiety disorder( GAD) .Methods A total of 120 patients with GAD were randomly divided into study group(60 cases) treated with EEG-biofeedback therapy combined with tandospirone for 6 weeks and control group (60 cases) treated with tandospirone monotherapy for 6 weeks.They were assessed with the Hamilton Anxiety Rating Scale(HAMA), Self-Rating Anxiety Scale(SAS) and Treatment Emergent Symptom Scale (TESS) at baseline and the 2nd, 4th, 6th weekend of treatment for effectiveness and side effects.Results The scores of HAMA and SAS in study group at the 2nd,4th, 6th weekend were all significantly lower than those at baseline (P <0.05), but in control group at the 4th and 6th weekend the scores mentioned above were significantly lower than those at baseline (P<0.05).At the 2nd, 4th and 6th weekend of treatment, the scores of HAMA and SAS in study group were all significantly lower than those in control group(P<0.05).At the 6th weekend of treatment, the effective rates in study group were significantly higher than those in control group (P<0.05).There was no significant difference between two groups in the incidence rate of side effects (P>0.05).Conclusion It’s effective, rapid and safe for EEG-biofeedback therapy combined with tandospirone to treat the patients with GAD.