CAJ | 학술논문

目的：探讨氨磺必利联合文拉法辛治疗老年期抑郁症的临床疗效和安全性。方法将92例老年抑郁症患者随机分为氨磺必利联合文拉法辛组（研究组）47例和文拉法辛组（对照组）45例，治疗并观察6周。于治疗前及治疗后第1、2、4和6周末采用17项汉密尔顿抑郁量表（HAMD-17）评定疗效，用治疗中需处理的不良反应症状量表（TESS）评定药物不良反应。结果治疗后第1、2、4、6周末两组患者HAMD-17评分均较各自治疗前降低（ P＜0．05），且治疗后第2、4、6周末研究组HAMD-17评分均低于对照组（P＜0．05）。治疗后第6周末，两组患者HAMD-17各因子分（体质量因子除外）均较各自治疗前降低（P＜0．05），且研究组低于对照组（P＜0．05）。两组间药物不良反应发生率比较差异无统计学意义（P＞0．05）。结论氨磺必利联合文拉法辛治疗老年期抑郁症的疗效优于单用文拉法辛，且不良反应并未增加。
목적：탐토안광필리연합문랍법신치료노년기억욱증적림상료효화안전성。방법장92례노년억욱증환자수궤분위안광필리연합문랍법신조（연구조）47례화문랍법신조（대조조）45례，치료병관찰6주。우치료전급치료후제1、2、4화6주말채용17항한밀이돈억욱량표（HAMD-17）평정료효，용치료중수처리적불량반응증상량표（TESS）평정약물불량반응。결과치료후제1、2、4、6주말량조환자HAMD-17평분균교각자치료전강저（ P＜0．05），차치료후제2、4、6주말연구조HAMD-17평분균저우대조조（P＜0．05）。치료후제6주말，량조환자HAMD-17각인자분（체질량인자제외）균교각자치료전강저（P＜0．05），차연구조저우대조조（P＜0．05）。량조간약물불량반응발생솔비교차이무통계학의의（P＞0．05）。결론안광필리연합문랍법신치료노년기억욱증적료효우우단용문랍법신，차불량반응병미증가。
Objective To investigate the clinical effect and safety of amisulpride combined with venlafaxine in the treatment ofseniledepression.Methods 92patientswithseniledepressionwererandomlydividedintostudygroup(47cases)treated with amisulpride combined with venlafaxine for 6 weeks and control group (45 cases) treated with venlafaxine monotherapy for 6 weeks.Curative effect and side effect were evaluated with Hamilton Depression Rating Scale-17 items ( HAMD-17 ) and Treatment Emergent Symptom Scale ( TESS) respectively at baseline and at the end of the 1st, 2nd, 4th, 6th week of the treatment.Results Total scores of HAMD-17 in both groups decreased significantly at the end of the 1st, 2nd, 4th, 6th week compared with the baseline (P<0.05), and total scores of HAMD-17 in study group were significantly lower than those in control group at the end of the 2nd, 4thand 6th week of the treatment (P<0.05).At the end of the 6th week, all factor scores of HAMD-17 except the factor of weight in both groups decreased significantly compared with the baseline (P<0.05), and factor scores mentioned above in study group were significantly lower than those in control group (P<0.05).There was no significant difference in incidence of adverse reactions between the two groups ( P >0.05).Conclusion Amisulpride combined with venlafaxine is more effective than venlafaxine monotherapy in the treatment of senile depression without the extra increase of side effects.