CAJ | 학술논문

目的：评价OPG基因A163G和T950C的多态性与骨质疏松发病风险的相关性。方法在万方数据库、中国知网、中国生物医学文献数据库、PubMed数据库中全面检索关于OPG基因启动子A163G和T950C多态性与骨质疏松相关的文献，对纳入的文献进行质量评价，并采用RevMan5．3软件进行meta分析。结果共有13篇文献被纳入本次的meta分析，关于A163G的文献有7篇，累计骨质疏松病例组805人，健康对照组948人；关于T950C的文献有8篇，累计骨质疏松病例组1286人，健康对照组1252人。关于A163G的meta分析显示等位基因G可能会增加骨质疏松的风险[ OR＝1．37，95％CI：1．12－1．68，P＝0．003]，在高加索人、男性和女性及绝经后妇女的亚组分析中显示同样的结果。关于T950C的meta分析显示等位基因T、C在增加骨质疏松的风险上无统计学意义[OR＝1．03，95％CI：0．82－1．28， P＝0．004]，在种族和性别的亚组分析中同样无统计学意义。结论 OPG基因T950C的多态性并没有证实与骨质疏松的风险有关，但A163G的多态性可能会增加骨质疏松的风险。
목적：평개OPG기인A163G화T950C적다태성여골질소송발병풍험적상관성。방법재만방수거고、중국지망、중국생물의학문헌수거고、PubMed수거고중전면검색관우OPG기인계동자A163G화T950C다태성여골질소송상관적문헌，대납입적문헌진행질량평개，병채용RevMan5．3연건진행meta분석。결과공유13편문헌피납입본차적meta분석，관우A163G적문헌유7편，루계골질소송병례조805인，건강대조조948인；관우T950C적문헌유8편，루계골질소송병례조1286인，건강대조조1252인。관우A163G적meta분석현시등위기인G가능회증가골질소송적풍험[ OR＝1．37，95％CI：1．12－1．68，P＝0．003]，재고가색인、남성화녀성급절경후부녀적아조분석중현시동양적결과。관우T950C적meta분석현시등위기인T、C재증가골질소송적풍험상무통계학의의[OR＝1．03，95％CI：0．82－1．28， P＝0．004]，재충족화성별적아조분석중동양무통계학의의。결론 OPG기인T950C적다태성병몰유증실여골질소송적풍험유관，단A163G적다태성가능회증가골질소송적풍험。
Objective To evaluate the relationship between OPG gene A163G and T950C polymorphisms and the risk of osteoporosis.Methods The relationship between OPG gene promoter T950C and A163G polymorphisms and osteoporosis in the literatures of Wanfang, CNKI, CBM, and PubMed was comprehensively searched.Data extracted from the literatures were evaluated The statistical analysis was conducted using a RevMan5.3 software.Results Thirteen published articles were selected for meta-analysis.Among them, there were 7 studies about A163G, including 805 subjects in the osteoporosis group and 948 subjects in the healthy control group.There were 8 studies about T950C, including 1286 subjects in the osteoporosis group and 1252 subjects in the healthy control group.Meta-analysis for A163G showed that allele G increased the risk of osteoporosis ( OR=1.37, 95%CI:1.12-1.68, P=0.003).Stratified analysis showed that the magnitude of the effect was similar in Caucasian people, males and females, and postmenopausal women.Meta-analysis for T950C showed that allele T/C had no statistical significance on the risk of osteoporosis (OR=1.03, 95% CI: 0.82 -1.28, P=0.004).Analysis in the subgroups also showed no statistical significance.Conclusion T950C polymorphisms are not associated with the risk of osteoporosis. However, A163G polymorphisms may increase the risk of osteoporosis.