CAJ | 학술논문

目的：探讨丹红注射液联合体外反搏治疗对急性冠脉综合征患者经皮冠状动脉介入术（PCI）后血浆炎症因子水平的影响。方法选取2012年11月~2014年8月在青岛大学附属医院因急性冠脉综合征行PCI手术，后转入青岛大学附属心血管病医院治疗的患者118例，其中男性68例，女性50例，按随机数表法分为Ⅰ组（n=38）、Ⅱ组（n=40）、Ⅲ组（n=40）。三组患者均给予常规治疗，Ⅰ组给予常规治疗，Ⅱ组在常规治疗基础上给予0.9%氯化钠250 ml或5%葡萄糖250 ml+丹红注射液40 ml静脉滴注1/日，Ⅲ组在常规治疗基础上给予0.9%氯化钠250 ml或5%葡萄糖250 ml +丹红注射液40 ml静脉滴注1/日及体外反搏治疗（1h/次，1/日），连续治疗14d。PCI术前1d、PCI术后1天（24h±2h）、治疗14d时测定高敏C反应蛋白（hsCRP）、血清细胞间粘附分子-1（ICAM-1）和血管细胞粘附分子-1（VCAM-1）。结果Ⅰ组有2例、Ⅱ组有1例、Ⅲ组有3例由于不能耐受体外反搏或病情加重中途退出试验。与PCI术前1d比较，PCI术后1d三组hsCRP、ICAM-1和VCAM-1均升高，差别有统计学意义（P＜0.05）；用药14d时，与Ⅰ组相比，Ⅱ组、Ⅲ组hsCRP、ICAM-1、VCAM-1较前降低，差异有统计学意义（P＜0.05）；与Ⅱ组相比，Ⅲ组hsCRP、ICAM-1、VCAM-1降低，差别有统计学意义（P＜0.05）。结论丹红联合体外反博能降低急性冠脉综合征患者PCI术后的炎症因子水平。
목적：탐토단홍주사액연합체외반박치료대급성관맥종합정환자경피관상동맥개입술（PCI）후혈장염증인자수평적영향。방법선취2012년11월~2014년8월재청도대학부속의원인급성관맥종합정행PCI수술，후전입청도대학부속심혈관병의원치료적환자118례，기중남성68례，녀성50례，안수궤수표법분위Ⅰ조（n=38）、Ⅱ조（n=40）、Ⅲ조（n=40）。삼조환자균급여상규치료，Ⅰ조급여상규치료，Ⅱ조재상규치료기출상급여0.9%록화납250 ml혹5%포도당250 ml+단홍주사액40 ml정맥적주1/일，Ⅲ조재상규치료기출상급여0.9%록화납250 ml혹5%포도당250 ml +단홍주사액40 ml정맥적주1/일급체외반박치료（1h/차，1/일），련속치료14d。PCI술전1d、PCI술후1천（24h±2h）、치료14d시측정고민C반응단백（hsCRP）、혈청세포간점부분자-1（ICAM-1）화혈관세포점부분자-1（VCAM-1）。결과Ⅰ조유2례、Ⅱ조유1례、Ⅲ조유3례유우불능내수체외반박혹병정가중중도퇴출시험。여PCI술전1d비교，PCI술후1d삼조hsCRP、ICAM-1화VCAM-1균승고，차별유통계학의의（P＜0.05）；용약14d시，여Ⅰ조상비，Ⅱ조、Ⅲ조hsCRP、ICAM-1、VCAM-1교전강저，차이유통계학의의（P＜0.05）；여Ⅱ조상비，Ⅲ조hsCRP、ICAM-1、VCAM-1강저，차별유통계학의의（P＜0.05）。결론단홍연합체외반박능강저급성관맥종합정환자PCI술후적염증인자수평。
Objective To investigate the influence of Danhong Injection combining external counterpulsation (ECP) on inflammatory factors in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI).Methods The patients (n=118, male 68 and female 50) were chosen from Nov. 2012 to Aug. 2014, and divided randomly into group I (n=38), group II (n=40) and group III (n=40). All groups were given routine treatment (including aspirin, clopidogrel, statins, ACEI, ARB, β-receptor blockers, nitrates and low molecular weight heparin). Group I was given routine treatment only, group II was additionally given 0.9% sodium chloride injection (250 mL) or 5% glucose (250 mL) and Danhong Injection (40 mL), and group III was additionally given 0.9%sodium chloride injection (250 mL) or 5% glucose (250 mL) and Danhong Injection (40 mL) and ECP (1 h/time, 1 time/d) for 14 d. The levels of high-sensitivity C-reactive protein (hs-CRP), intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were detected 1 d before PCI, 1 d after PCI (24 h± 2 h) and after PCI for 14 d.Results There were 2 patients in group I, 1 in group II and 3 in group III dropped out from the study because they cannot bear ECP or their disease exacerbated. The levels of hs-CRP, ICAM-1 and VCAM-1 increased in 3 groups 1 d after PCI compared with those 1 d before PCI (P<0.05). The levels of hs-CRP, ICAM-1 and VCAM-1 decreased in group II and group III compared with group I after treatment for 14 d (P<0.05), and decreased in group III compared with group II (P<0.05).Conclusion Danhong Injection combining ECP can reduce the levels of inflammatory factors in patients with ACS after PCI.