CAJ | 학술논문

目的：观察麝香保心丸对强负荷训练者心肌损伤和C反应蛋白的影响。方法选择某大学体育系2014年9月入学男性新生136名，年龄17~20（18.2±1.4）岁。使用随机数字表分为A、B两组，每组各68例。A组在接受训练前口服麝香保心丸，共两周；B组训练前不实施任何干预。然后按设计要求于晨起后空腹越野跑5 km，时间控制在25~30min。分别抽取静脉血比较两组训练前、训练后即刻和次日肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）、心肌肌钙蛋白I（cTnI）、脑钠肽（BNP）和C反应蛋白（CRP）的变化。结果训练后即刻较训练前两组BNP、CRP升高，差异有统计学意义（P均＜0.05）。两组训练后次日较训练前血清CK、CK-MB、cTnI、BNP和CRP均升高，差异有统计学意义（P均＜0.05）。与B组比较，A组训练后次日CK[（226.30±70.10）U/Lvs.（199.40±32.80）U/L]、CK-MB[（31.50±10.90）U/Lvs.（21.20±6.20）U/L]、cTnI [（0.104±0.033）μg/Lvs.（0.076±0.042）μg/L]、BNP[（102.44±42.36）μg/Lvs.（88.15±27.28）μg/L]和CRP[（6.13±2.76）μg/Lvs.（3.33±1.57）μg/L]均降低，差异有统计学意义（P均＜0.05）。结论训练前口服麝香保心丸能够减轻强负荷训练的心肌损伤。
목적：관찰사향보심환대강부하훈련자심기손상화C반응단백적영향。방법선택모대학체육계2014년9월입학남성신생136명，년령17~20（18.2±1.4）세。사용수궤수자표분위A、B량조，매조각68례。A조재접수훈련전구복사향보심환，공량주；B조훈련전불실시임하간예。연후안설계요구우신기후공복월야포5 km，시간공제재25~30min。분별추취정맥혈비교량조훈련전、훈련후즉각화차일기산격매（CK）、기산격매동공매（CK-MB）、심기기개단백I（cTnI）、뇌납태（BNP）화C반응단백（CRP）적변화。결과훈련후즉각교훈련전량조BNP、CRP승고，차이유통계학의의（P균＜0.05）。량조훈련후차일교훈련전혈청CK、CK-MB、cTnI、BNP화CRP균승고，차이유통계학의의（P균＜0.05）。여B조비교，A조훈련후차일CK[（226.30±70.10）U/Lvs.（199.40±32.80）U/L]、CK-MB[（31.50±10.90）U/Lvs.（21.20±6.20）U/L]、cTnI [（0.104±0.033）μg/Lvs.（0.076±0.042）μg/L]、BNP[（102.44±42.36）μg/Lvs.（88.15±27.28）μg/L]화CRP[（6.13±2.76）μg/Lvs.（3.33±1.57）μg/L]균강저，차이유통계학의의（P균＜0.05）。결론훈련전구복사향보심환능구감경강부하훈련적심기손상。
Objective To observe the influence of Shexiang Baoxin Wan on myocardial injury and C-reactive protein (CRP) in trainers with intensity load training.Methods Male freshmen (n=136 aged from 17 to 20, average age=18.2±1.4, and enrolled on Sept. 2014) were chosen from the Department of Physical Education of a university, and randomly divided into group A and group B (eachn=68). The group A was given orally Shexiang Baoxin Wan before training and group B was not given any intervention. All freshmen were arranged to have a cross-country race for 5 km from 25 min to 30 min after getting up in the morning. The changes of creatine kinase (CK), Creatine kinase MB (CK-MB), cardiac troponin I (cTnI), B-type natriuretic peptide (BNP) and C-reactive protein (CRP) were detected and compared in 2 groups before training, immediate after training and in the next day.Resutls The levels of BNP and CRP increased in 2 groups immediate after training (allP<0.05). The levels of serum CK, CK-MB, cTnI, BNP and CRP increased in 2 groups in the next day (allP<0.05). The levels of serum CK [(226.30± 70.10) U/Lvs. (199.40±32.80) U/L], CK-MB [(31.50±10.90) U/Lvs. (21.20±6.20) U/L], cTnI [(0.104±0.033) g/Lvs. (0.076±0.042) g/L], BNP [(102.44±42.36) g/Lvs. (88.15±27.28) g/L] and CRP [(6.13±2.76) g/Lvs. (3.33 ±1.57) g/L] decreased in group A compared with group B after training (allP<0.05).Conclusion Shexiang Baoxin Wan orally taken before training can relieve the myocardial injury due to intensity load training.