CAJ | 학술논문

目的：观察盐酸阿罗洛尔对原发性高血压患者焦虑抑郁情绪的影响。方法入选2014年1月~2014年6月间北京军区总医院心内科门诊初诊的1~2级中青年原发性高血压患者100例，其中男性62例，女性38例，年龄19～60岁，平均年龄（40.2±10.8）岁。随机分为阿罗洛尔组（n=50）和氨氯地平组（n=50）。阿罗洛尔组每日晨起服用盐酸阿罗洛尔；氨氯地平组服用苯磺酸氨氯地平，连续服药8周。分别于用药前及用药后8周记录患者24h动态血压、心率情况，贝克抑郁量表、状态焦虑问卷评估抑郁、焦虑水平变化。结果两组患者治疗后较治疗前血压均下降，差异有统计学意义（P均＜0.05）。与氨氯地平组比较，阿罗洛尔组治疗后心率显著下降，（77.8±11.0）次/minvs.（67.5±10.0）次/min，差异有统计学意义（P＜0.05）。与氨氯地平组比较，阿罗洛尔组焦虑水平下降，（37.9±10.2）分vs.（35.2±7.6）分，差异有统计学意义（P＜0.05）。结论盐酸阿罗洛尔在有效降压的同时，可降低高血压患者的焦虑水平。
목적：관찰염산아라락이대원발성고혈압환자초필억욱정서적영향。방법입선2014년1월~2014년6월간북경군구총의원심내과문진초진적1~2급중청년원발성고혈압환자100례，기중남성62례，녀성38례，년령19～60세，평균년령（40.2±10.8）세。수궤분위아라락이조（n=50）화안록지평조（n=50）。아라락이조매일신기복용염산아라락이；안록지평조복용분광산안록지평，련속복약8주。분별우용약전급용약후8주기록환자24h동태혈압、심솔정황，패극억욱량표、상태초필문권평고억욱、초필수평변화。결과량조환자치료후교치료전혈압균하강，차이유통계학의의（P균＜0.05）。여안록지평조비교，아라락이조치료후심솔현저하강，（77.8±11.0）차/minvs.（67.5±10.0）차/min，차이유통계학의의（P＜0.05）。여안록지평조비교，아라락이조초필수평하강，（37.9±10.2）분vs.（35.2±7.6）분，차이유통계학의의（P＜0.05）。결론염산아라락이재유효강압적동시，가강저고혈압환자적초필수평。
Objective To observe the influence of arotinolol on anxiety and depression in patients with primary hypertension.Methods The middle-aged and young patients with grade 1 or grade 2 primary hypertension (n=100, male 62, female 38, aged from 19 to 60 and average age=40.2±10.8) were chosen from Jan. 2014 to Jun. 2014. All patients were randomly divided into arotinolol group and amlodipine group (eachn=50) and were given drugs for 8 w continuously. The changes of 24 h ambulatory blood pressure (BP) and heart rate (HR) recorded, and depression and anxiety levels were reviewed by using Beck Depression Inventory and state-anxiety inventory (S-AI).Results BP decreased in 2 groups after treatment (allP<0.05). HR decreased significantly in arotinolol group compared with amlodipine group [(77.8±11.0) time/minvs. (67.5±10.0) time/min] after treatment (P<0.05). The level of anxiety decreased in arotinolol group compared with amlodipine group [(37.9±10.2)vs. (35.2±7.6), P<0.05].Conclusion Arotinolol can reduce the level of anxiety at the same time of decreasing BP effectively in hypertensive patients.