现代中西医结合杂志
現代中西醫結閤雜誌
현대중서의결합잡지
Modern Journal of Integrated Traditional Chinese and Western Medicine
2015年
32期
3565-3567,3568
,共4页
黄勇%黎家楼%梁景星%伍广锐
黃勇%黎傢樓%樑景星%伍廣銳
황용%려가루%량경성%오엄예
骨质疏松症%益肾壮骨汤%肾阳虚型%碱性磷酸酶%雌二醇%白细胞介素-6
骨質疏鬆癥%益腎壯骨湯%腎暘虛型%堿性燐痠酶%雌二醇%白細胞介素-6
골질소송증%익신장골탕%신양허형%감성린산매%자이순%백세포개소-6
postmenopausal osteoporosis%Yishen Zhuanggu decoction%Kidney Yang deficiency%ALP%E2%IL-6
目的：观察中西医结合治疗肾阳虚型绝经后骨质疏松症的临床疗效及对血清碱性磷酸酶（ ALP）、雌二醇（ E2）及白细胞介素－6（ IL－6）水平的影响。方法将80例肾阳虚型绝经后骨质疏松症女性患者随机分为治疗组与对照组各40例，对照组给予骨肽片口服，治疗组加用自拟益肾壮骨汤治疗，疗程均为28 d。比较2组中医证候疗效，治疗前后骨密度（ BMD）及ALP、E2、IL－6水平变化。结果治疗组治疗后神疲倦怠、畏寒肢冷、夜尿频多等中医证候积分均较治疗前、同期对照组明显降低（P均＜0．05）；治疗后2组BMD均较治疗前明显升高（P均＜0．05），且组间比较差异无统计学意义（P＞0．05）；但治疗组治疗后ALP、E2、IL－6水平较治疗前、同期对照组差异均有统计学意义（P均＜0．05）；2组治疗前、治疗1周时VAS评分比较差异均无统计学意义（P均＞0．05），治疗2，4周时治疗组较对照组VAS评分明显降低（ P均＜0．05）。结论中西医结合治疗肾阳虚型绝经后骨质疏松症疗效理想，可显著改善伴随症状，其可能与改善ALP、E2、IL－6水平有关。
目的：觀察中西醫結閤治療腎暘虛型絕經後骨質疏鬆癥的臨床療效及對血清堿性燐痠酶（ ALP）、雌二醇（ E2）及白細胞介素－6（ IL－6）水平的影響。方法將80例腎暘虛型絕經後骨質疏鬆癥女性患者隨機分為治療組與對照組各40例，對照組給予骨肽片口服，治療組加用自擬益腎壯骨湯治療，療程均為28 d。比較2組中醫證候療效，治療前後骨密度（ BMD）及ALP、E2、IL－6水平變化。結果治療組治療後神疲倦怠、畏寒肢冷、夜尿頻多等中醫證候積分均較治療前、同期對照組明顯降低（P均＜0．05）；治療後2組BMD均較治療前明顯升高（P均＜0．05），且組間比較差異無統計學意義（P＞0．05）；但治療組治療後ALP、E2、IL－6水平較治療前、同期對照組差異均有統計學意義（P均＜0．05）；2組治療前、治療1週時VAS評分比較差異均無統計學意義（P均＞0．05），治療2，4週時治療組較對照組VAS評分明顯降低（ P均＜0．05）。結論中西醫結閤治療腎暘虛型絕經後骨質疏鬆癥療效理想，可顯著改善伴隨癥狀，其可能與改善ALP、E2、IL－6水平有關。
목적：관찰중서의결합치료신양허형절경후골질소송증적림상료효급대혈청감성린산매（ ALP）、자이순（ E2）급백세포개소－6（ IL－6）수평적영향。방법장80례신양허형절경후골질소송증녀성환자수궤분위치료조여대조조각40례，대조조급여골태편구복，치료조가용자의익신장골탕치료，료정균위28 d。비교2조중의증후료효，치료전후골밀도（ BMD）급ALP、E2、IL－6수평변화。결과치료조치료후신피권태、외한지랭、야뇨빈다등중의증후적분균교치료전、동기대조조명현강저（P균＜0．05）；치료후2조BMD균교치료전명현승고（P균＜0．05），차조간비교차이무통계학의의（P＞0．05）；단치료조치료후ALP、E2、IL－6수평교치료전、동기대조조차이균유통계학의의（P균＜0．05）；2조치료전、치료1주시VAS평분비교차이균무통계학의의（P균＞0．05），치료2，4주시치료조교대조조VAS평분명현강저（ P균＜0．05）。결론중서의결합치료신양허형절경후골질소송증료효이상，가현저개선반수증상，기가능여개선ALP、E2、IL－6수평유관。
Objective It is to observe the clinical curative effect of therapy with Chinese integrated Chinese-western thera-py on postmenopausal osteoporosis with Kidney Yang deficiency and the serum levels of ALP, E2 and IL-6.Methods 80 pa-tients with postmenopausal osteoporosis with Kidney Yang deficiency were randomly divided into treatment group and control group, 40 cases in each group.The control group was given Ossotide tablets by oral administration, while the treatment group was added with Yishen Zhuanggu decoction, both the treatment courses were 28 days.The changes of curative effect of Chi-nese medicine syndrome, and the levels of BMD, ALP, E2 and IL-6 before and after treatment in both groups.Results The Chinese medicine syndrome scores of tireness, cold fear and limb, and much night urination were decreased after treatment compared with that before treatment and in control group after treatment in treatment group (P all<0.05).After treatment, BMD were increased obviously in both group compared with that before treatment (P all<0.05), and the difference between the two groups was not significant (P>0.05), but the differences in the levels of ALP, E2 and IL-6 after treatment in treat-ment group were significant compared with those before therapy and in control group after therapy (P all<0.05).There was no significant difference in VAS before treatment and 0ne week after treatment (P all>0.05), but the scores after 2, 4 weeks in treatment group were significantly lower than that in control group ( P<0.05).Conclusion Chinese integrated Chinese-western therapy has a satisfactory effect on postmenopausal osteoporosis with Kidney Yang deficiency, which can significantly improve the complicating symptoms, and the effect may be related with the improvements of the levels of ALP, E2 and IL-6.
