CAJ | 학술논문

目的：观察维格列汀对2型糖尿病合并冠心病患者血清脂联素、抵抗素水平的影响。方法将60例冠心病合并糖尿病患者随机分为2组，观察组给予维格列汀口服治疗，对照组给予二甲双胍口服治疗，2组均治疗10周。检测2组治疗前后血清脂联素（APN）、抵抗素（RET）、肿瘤坏死因子－α（TNF－α）、空腹血糖（FBG）和胰岛素（FINS）、总胆固醇（ TC）、三酰甘油（ TG）、游离脂肪酸（ FFA）水平，计算胰岛素敏感指数（ ISI）和胰岛素抵抗指数（ HOMA－IR）。结果治疗后对照组FBG、APN、RET、FFA均较治疗前明显改善（ P均＜0．05）；观察组除TC、TG无明显变化外，其余指标均较治疗前明显改善（P均＜0．05），且观察组改善情况明显优于对照组（P均＜0．05）。结论维格列汀能有效降低2型糖尿病合并冠心病患者血清RET水平，提高APN水平，改善胰岛素抵抗。
목적：관찰유격렬정대2형당뇨병합병관심병환자혈청지련소、저항소수평적영향。방법장60례관심병합병당뇨병환자수궤분위2조，관찰조급여유격렬정구복치료，대조조급여이갑쌍고구복치료，2조균치료10주。검측2조치료전후혈청지련소（APN）、저항소（RET）、종류배사인자－α（TNF－α）、공복혈당（FBG）화이도소（FINS）、총담고순（ TC）、삼선감유（ TG）、유리지방산（ FFA）수평，계산이도소민감지수（ ISI）화이도소저항지수（ HOMA－IR）。결과치료후대조조FBG、APN、RET、FFA균교치료전명현개선（ P균＜0．05）；관찰조제TC、TG무명현변화외，기여지표균교치료전명현개선（P균＜0．05），차관찰조개선정황명현우우대조조（P균＜0．05）。결론유격렬정능유효강저2형당뇨병합병관심병환자혈청RET수평，제고APN수평，개선이도소저항。
Objective It is to explore the effect of Vildagliptin on the adiponectin and resistin of patients with 2-diabetes mellitus complicating with coronary heart disease.Methods Sixty patients with coronary heart and 2-diabetes mellitus were divided into observation group and the control group randomly.The control group was treated by metformin orally and the obser-vation group was treated by vidagliptin orally.The level of APN, RET, TNF-α, FPG, FINS, TC, TG, FFA were deter-mined before and after treatment, and the index of ISI and HOMA-IR were calculated.Results After treatment, the levels of FBG, APN, RET and FFA were improved significantly compared with that before treatment (P all<0.05), all the indexes except TC, TG were improved significantly compared with that before treatment (P all<0.05) in observation group, and the improvements were better than that in the control group (P all<0.05).Conclusion Vildagliptin could significantly reduce the level of RET, increase the level of APN and improve the insulin resistance of patients with 2-diabetes mellitus with corinary heart disease.