CAJ | 학술논문

目的：观察老年肺癌患者GP方案围治疗期恶心、呕吐现况及对Morse 跌倒评分指标影响。方法选择2013年1~12月在辽宁省肿瘤医院住院接受GP方案化疗的老年肺癌患者95例,患者在开始化疗前、第2周期开始前及化疗结束后分别接受恶心、呕吐等级指标、恶心问卷(NP问卷)和Morse跌倒评估量表评估,并进行自身对照比较。结果接受GP方案化疗老年肺癌患者各周期无恶心、呕吐者明显少于化疗前,同时轻、中、重度恶心、呕吐者均明显多于开始化疗前,差异有高度统计学意义(P<0.01)。接受GP方案化疗老年肺癌患者第2周期开始前及化疗结束后NP各项因子分及NP总分均明显高于开始化疗前,差异有统计学意义(P<0.05)。接受GP方案化疗老年肺癌患者第2周期开始前及化疗结束后Morse量表中多数条目分及Morse总分均明显高于开始化疗前,差异有统计学意义(P<0.05)。95例接受GP方案化疗肺癌患者中,围治疗期发生化疗所致恶心呕吐(CINV)者81例(85.26%),未发生CINV者14例(14.74%),CINV者Morse量表中各个条目分及Morse总分均明显高于无CINV患者,差异有统计学意义(P<0.05)。结论接受GP方案化疗老年肺癌患者围治疗期间发生恶心、呕吐频度高、程度重,并明确影响到了Morse跌倒评分指标。
목적：관찰노년폐암환자GP방안위치료기악심、구토현황급대Morse 질도평분지표영향。방법선택2013년1~12월재요녕성종류의원주원접수GP방안화료적노년폐암환자95례,환자재개시화료전、제2주기개시전급화료결속후분별접수악심、구토등급지표、악심문권(NP문권)화Morse질도평고량표평고,병진행자신대조비교。결과접수GP방안화료노년폐암환자각주기무악심、구토자명현소우화료전,동시경、중、중도악심、구토자균명현다우개시화료전,차이유고도통계학의의(P<0.01)。접수GP방안화료노년폐암환자제2주기개시전급화료결속후NP각항인자분급NP총분균명현고우개시화료전,차이유통계학의의(P<0.05)。접수GP방안화료노년폐암환자제2주기개시전급화료결속후Morse량표중다수조목분급Morse총분균명현고우개시화료전,차이유통계학의의(P<0.05)。95례접수GP방안화료폐암환자중,위치료기발생화료소치악심구토(CINV)자81례(85.26%),미발생CINV자14례(14.74%),CINV자Morse량표중각개조목분급Morse총분균명현고우무CINV환자,차이유통계학의의(P<0.05)。결론접수GP방안화료노년폐암환자위치료기간발생악심、구토빈도고、정도중,병명학영향도료Morse질도평분지표。
Objective To evaluate the effect of GP chemotherapy on nausea, vomit and Morse fall scales of elder pa-tients with lung cancer. Methods From January to November 2013, in Liaoning Cancer Hospital & Institute, 95 pa-tients with lung cancer treated with combined GP regime chemotherapy were selected, The indicator of nausea and vomiting, nausea questionnaire (NP) and Morse fall scales were evaluated compared with themselves before chemothera-py, the second chemotherapy cycle and after all the chemotherapy cycles. Results Non-nausea and non-vomit in the patients with elderly lung cancer at any time after chemotherapy were significantly less than that before chemotherapy, and patients with mild and severe nausea and vomit were more than those before chemotherapy, the differences were statistically significant (P<0.01). NP questionnaire every factor and total scores before the second chemotherapy and af-ter all the chemotherapy were significantly higher than those before the first chemotherapy, the differences were statistical-ly significant (P<0.05). Most item scales and total scale in the Morse fall scale testing were significantly higher than those before chemotherapy, the differences were statistically significant (P<0.05). Among 95 elderly patients with lung can-cer, 81 patients (85.26%) occurred CINV and 14 patients (14.74%) were without CINV. The every item scale and Morse total scale of CINV patients were significantly higher than those of non-CINV patinets, the differences were statistically significant (P< 0.05). Conclusion Higher, worse nausea and vomiting during chemotherapy are associated with GP regime chemotherapy in elderly patients with lung cancer, and greatly affect Morse fall scales.