中国医药导报
中國醫藥導報
중국의약도보
China Medical Herald
2015年
29期
70-73
,共4页
胃癌%NF-资B%免疫组织化学
胃癌%NF-資B%免疫組織化學
위암%NF-자B%면역조직화학
Gastric cancer%NF-κB%Immunohistochemistry
目的：检测胃癌组织中核因子资B(nuclear factor kappa binding,NF-资B)的表达情况,探索NF-资B与临床病理的相关性。方法选取2004年1月~2009年1月四川省人民医院病理科收入的50例胃癌患者和同期的50例非肿瘤患者,应用免疫组织化学方法(SP法)检测胃癌患者病灶组织及癌旁组织、非肿瘤患者胃黏膜组织的NF-资B,比较分析不同临床病例特征者的NF-资B的表达情况,并比较不同的NF-资B表达情况者的5年生存率。结果胃癌患者胃癌组织、癌旁组织和非肿瘤患者胃黏膜组织中NF-资B蛋白阳性表达率分别为76.0%(38/50)、4.0%(2/50)和16.0%(8/50),差异均有统计学意义(字2=20.404,43.511,6.655,均P<0.05)；胃癌组织中NF-资B的表达与脉管侵犯、浸润程度、淋巴结转移、当肿瘤直径<5 cm时,与肿瘤大小呈正相关(r=0.318,0.243,0.315,0.350；P=0.002,0.002,0.035,0.001),与分化程度无相关性(r=0.119,P=0.242),非肿瘤患者NF-资B低表达者的5年生存率显著高于高表达者(P<0.05)。结论 NF-资B阳性表达与胃癌的侵袭、转移密切相关,检测NF-资B的表达对胃癌病情监测及转移潜能及预后估计等方面有重要参考价值。
目的：檢測胃癌組織中覈因子資B(nuclear factor kappa binding,NF-資B)的錶達情況,探索NF-資B與臨床病理的相關性。方法選取2004年1月~2009年1月四川省人民醫院病理科收入的50例胃癌患者和同期的50例非腫瘤患者,應用免疫組織化學方法(SP法)檢測胃癌患者病竈組織及癌徬組織、非腫瘤患者胃黏膜組織的NF-資B,比較分析不同臨床病例特徵者的NF-資B的錶達情況,併比較不同的NF-資B錶達情況者的5年生存率。結果胃癌患者胃癌組織、癌徬組織和非腫瘤患者胃黏膜組織中NF-資B蛋白暘性錶達率分彆為76.0%(38/50)、4.0%(2/50)和16.0%(8/50),差異均有統計學意義(字2=20.404,43.511,6.655,均P<0.05)；胃癌組織中NF-資B的錶達與脈管侵犯、浸潤程度、淋巴結轉移、噹腫瘤直徑<5 cm時,與腫瘤大小呈正相關(r=0.318,0.243,0.315,0.350；P=0.002,0.002,0.035,0.001),與分化程度無相關性(r=0.119,P=0.242),非腫瘤患者NF-資B低錶達者的5年生存率顯著高于高錶達者(P<0.05)。結論 NF-資B暘性錶達與胃癌的侵襲、轉移密切相關,檢測NF-資B的錶達對胃癌病情鑑測及轉移潛能及預後估計等方麵有重要參攷價值。
목적：검측위암조직중핵인자자B(nuclear factor kappa binding,NF-자B)적표체정황,탐색NF-자B여림상병리적상관성。방법선취2004년1월~2009년1월사천성인민의원병이과수입적50례위암환자화동기적50례비종류환자,응용면역조직화학방법(SP법)검측위암환자병조조직급암방조직、비종류환자위점막조직적NF-자B,비교분석불동림상병례특정자적NF-자B적표체정황,병비교불동적NF-자B표체정황자적5년생존솔。결과위암환자위암조직、암방조직화비종류환자위점막조직중NF-자B단백양성표체솔분별위76.0%(38/50)、4.0%(2/50)화16.0%(8/50),차이균유통계학의의(자2=20.404,43.511,6.655,균P<0.05)；위암조직중NF-자B적표체여맥관침범、침윤정도、림파결전이、당종류직경<5 cm시,여종류대소정정상관(r=0.318,0.243,0.315,0.350；P=0.002,0.002,0.035,0.001),여분화정도무상관성(r=0.119,P=0.242),비종류환자NF-자B저표체자적5년생존솔현저고우고표체자(P<0.05)。결론 NF-자B양성표체여위암적침습、전이밀절상관,검측NF-자B적표체대위암병정감측급전이잠능급예후고계등방면유중요삼고개치。
Objective To detect the expression of nuclear factor κB in gastric cancer tissue (NF-κB) and explore its correlation with clinicopathologic. Methods From January 2004 to January 2009, 50 patients with gastric cancer and 50 cases without tumor in Sichuan Provincial People's Hospital were selected, then the expression of NF-κB in lesion tis-sue and adjacent tissues of patients with lung cancer and gastric mucosa tissue of non-tumer patients were detected with immunohistochemistry (SP method). The expression of NF-κB with different clinicopathological features were com-pared,and the 5-year survival rates were observed. Results The positive expression rates of NF-κB in lesion tissue and adjacent tissues of patients with lung cancer and in gastric mucosa tissue of non-tumer patients were respectively 76.0%(38/50),4.0%(2/50) and 16.0%(8/50),the differences were statistically significant(χ2=20.404, 43.511, 6.655,P<0.05),In lesion tissue, the expression of NF-κB was positive correlation with vascular invasion, degree of infiltration, lymph node metastasis and tumor size when the size was 5 cm below (r=0.318, 0.243, 0.315, 0.350;P=0.002, 0.002, 0.035, 0.001),but no correlation with the differentiated degree (r=0.119, P=0.242). 5-year survival rates of patients with low NF-κB expression was significantly higher than that with high NF-κB expression (P<0.05). Conclusion NF-κB expression is closely related with the invasion and metastasis in gastric cancer, and the detection of it is very impor-tant to monitor the condition and metastatic potential, and evaluate prognosis of gastric cancer.
