CAJ | 학술논문

目的：探讨双相障碍稳定期患者认知功能损害的特点及其相关因素。方法选取在我院接受治疗的稳定期双相障碍患者105例作为患者组，选取103例健康体检者作为健康对照组。采用数字符号测验、数字广度测验、连线测验（TMT）A和B及威斯康星卡片分类测验（WCST）对受试者的认知功能进行评定。结果患者组的数字符号测验、数字广度测验、TMT －A、TMT －B、WSCT测验成绩均显著低于健康对照组，差异有统计学意义（P ＜0．05）；将患者组分为有精神病症状组和无精神病症状组，通过方差分析，显示三组之间各项测验成绩的差异均有统计学意义（P＜0．05），进一步进行LSD检验，结果显示有精神病症状组上述指标均比健康对照组差，差异有统计学意义（P＜0．05），无精神病症状组除数字广度测验（顺背）外，其余各项指标均比健康对照组差（P＜0．05）；进行相关性分析发现，患者组的数字符号测验、数字广度测验（倒背、总分）、TMT －A、TMT －B成绩与患者的汉密尔顿抑郁量表（HAMD）和Young氏躁狂量表（YMRS）评分之间具有相关性（P ＜0．05），患者的发病年龄、稳定时间和认知功能评分之间无相关性（P ＞0．05）。结论稳定期双相障碍患者存在注意力、记忆力和执行功能损害，其认知功能与 HAMD、YMRS评分存在一定的相关性。
목적：탐토쌍상장애은정기환자인지공능손해적특점급기상관인소。방법선취재아원접수치료적은정기쌍상장애환자105례작위환자조，선취103례건강체검자작위건강대조조。채용수자부호측험、수자엄도측험、련선측험（TMT）A화B급위사강성잡편분류측험（WCST）대수시자적인지공능진행평정。결과환자조적수자부호측험、수자엄도측험、TMT －A、TMT －B、WSCT측험성적균현저저우건강대조조，차이유통계학의의（P ＜0．05）；장환자조분위유정신병증상조화무정신병증상조，통과방차분석，현시삼조지간각항측험성적적차이균유통계학의의（P＜0．05），진일보진행LSD검험，결과현시유정신병증상조상술지표균비건강대조조차，차이유통계학의의（P＜0．05），무정신병증상조제수자엄도측험（순배）외，기여각항지표균비건강대조조차（P＜0．05）；진행상관성분석발현，환자조적수자부호측험、수자엄도측험（도배、총분）、TMT －A、TMT －B성적여환자적한밀이돈억욱량표（HAMD）화Young씨조광량표（YMRS）평분지간구유상관성（P ＜0．05），환자적발병년령、은정시간화인지공능평분지간무상관성（P ＞0．05）。결론은정기쌍상장애환자존재주의력、기억력화집행공능손해，기인지공능여 HAMD、YMRS평분존재일정적상관성。
Objective To explore the characteristics and related factors of cognitive impairment in patients with bipolar disorder(BD) in stationary phase .Methods A total of 105 cases with BD in station‐ary phase (patient group) and 100 healthy controls (control group) were assessed with digit symbol , digit span ,Trail Making Test -A (TMT -A) ,Trail Making Test-B (TMT -B) and Wisconsin Card Sorting Test (WSCT) .Results The performance of digit symbol ,digit span ,TMT -A ,TMT -B and WCST in patient group were significantly worse than those in control group (P < 0 .05);BD patients were divided into subgroups with and without psychotic symptoms ,and there were significant differences in the performance of digit symbol ,digit span ,TMT -A ,TMT -B and WCST between the two sub‐groups (P< 0 .05) .LSD test indicated that parameters mentioned above in the two subgroups other than the digit span in subgroup without psychiatric symptoms were significantly worse than those in control group (P < 0 .05) .In patient group ,the scores of HAMD or YMRS were significantly correlated with the performance of digit symbol ,digit span ,TMT -A and TMT -B (P< 0 .05) .There was no signifi‐cant correlation between age of onset ,length of stationary phase and the performance of cognitive func‐tion (P > 0 .05) .Conclusions Cognitive function such as attention ,memory and executive function are impaired in BD patients in stationary phase ;there may be some correlations between the HAMD ,YMRS score and cognitive function .