CAJ | 학술논문

目的：评价采用重组组织型纤溶酶原激活剂（rt－PA）静脉溶栓治疗急性脑梗死（ACI）的临床疗效及安全性。方法检索中国知网（CNKI）、中国生物医学文献数据库（CBMdise）、万方数据库从建库至2015年3月的参考文献，筛选所有使用rt－PA静脉溶栓治疗ACI的随机对照试验（RCT ）研究，由两名评价员独立检索和评价文献质量，采用RevMan5．2软件进行M eta分析。结果共纳入8篇RCT研究，试验组248例，对照组298例。采用rt－PA静脉溶栓治疗的患者神经功能缺损（NIHSS）评分、日常生活活动能力（ADL ）评分改善显著，出血的风险增加，两组间差异均有统计学意义（ P ＜0.05）。结论中国现有数据库文献显示，rt－PA静脉溶栓治疗可显著改善脑梗死后神经功能和日常生活能力，但出血的风险增加。
목적：평개채용중조조직형섬용매원격활제（rt－PA）정맥용전치료급성뇌경사（ACI）적림상료효급안전성。방법검색중국지망（CNKI）、중국생물의학문헌수거고（CBMdise）、만방수거고종건고지2015년3월적삼고문헌，사선소유사용rt－PA정맥용전치료ACI적수궤대조시험（RCT ）연구，유량명평개원독립검색화평개문헌질량，채용RevMan5．2연건진행M eta분석。결과공납입8편RCT연구，시험조248례，대조조298례。채용rt－PA정맥용전치료적환자신경공능결손（NIHSS）평분、일상생활활동능력（ADL ）평분개선현저，출혈적풍험증가，량조간차이균유통계학의의（ P ＜0.05）。결론중국현유수거고문헌현시，rt－PA정맥용전치료가현저개선뇌경사후신경공능화일상생활능력，단출혈적풍험증가。
Objective To evaluate the clinical efficacy and safety of recombinant tissue -type plas‐minogen activator (rt-PA) in the treatment of acute cerebral infarction (ACI) .Methods The CNKI , CBMdise and Wanfang Database (all till Mar ,2015) were retrieved by computer to collect randomized controlled trials(RCTs) of rt -PA in the treatment of ACI .Two reviewers independently retrieved and evaluated literature quality .The RevMan 5 .2 software was used for Meta -analysis .Results Eight RCTs were included in the study ,248 cases in the treatment group (using rt-PA) and 298 cases in the control group (using conventional therapy) .Meta-analysis showed that there were significant difference in the NIHSS score ,ADL score and risk of bleeding between the treatment group and control group (P < 0 .05) .Conclusions The Meta-analysis results from databases indicate that rt -PA can improve the neurological function ,the activities of daily living and increase the risk of bleeding in ACI .