健康研究
健康研究
건강연구
Health Research
2015年
5期
525-527
,共3页
陈勇%何艇%俞四喜%邓秋萍%毛国章
陳勇%何艇%俞四喜%鄧鞦萍%毛國章
진용%하정%유사희%산추평%모국장
阿司匹林%低分子右旋糖酐%梗死前%心绞痛%评价
阿司匹林%低分子右鏇糖酐%梗死前%心絞痛%評價
아사필림%저분자우선당항%경사전%심교통%평개
aspirin%dextran%pre-infarction angina%evaluation
目的:评价阿司匹林联合低分子右旋糖酐治疗梗死前心绞痛患者的临床疗效,探讨其临床适用性。方法78例梗死前心绞痛患者简单随机分为观察组、对照组各39例,对照组患者采用常规治疗,观察组患者在此基础上采用阿司匹林合并低分子右旋糖酐注射液治疗。观察并记录两组患者的心绞痛发作频率、持续时间、硝酸甘油用量,用药期间的不良反应情况,处理结果和主要供血冠状动脉的血流情况。结果治疗前两组患者的心绞痛发作频率、持续时间和硝酸甘油用量比较,差异均无统计学意义( P>0.05);治疗后均显著改善,且观察组患者改善情况显著优于对照组(P<0.05)。观察组患者的心脏事件总发生率(23.08%)显著低于对照组(χ2=13.35,P<0.05);两组患者治疗前左心室前降支的血流参数之间没有明显差异(P>0.05),治疗后均显著升高,且观察组显著高于对照组(均P<0.05)。两组患者用药期间均未出现明显严重的不良症状。结论阿司匹林联合低分子右旋糖酐治疗急诊梗死前心绞痛效果明显,可降低心律失常、心肌梗死和心力衰竭的发生率。
目的:評價阿司匹林聯閤低分子右鏇糖酐治療梗死前心絞痛患者的臨床療效,探討其臨床適用性。方法78例梗死前心絞痛患者簡單隨機分為觀察組、對照組各39例,對照組患者採用常規治療,觀察組患者在此基礎上採用阿司匹林閤併低分子右鏇糖酐註射液治療。觀察併記錄兩組患者的心絞痛髮作頻率、持續時間、硝痠甘油用量,用藥期間的不良反應情況,處理結果和主要供血冠狀動脈的血流情況。結果治療前兩組患者的心絞痛髮作頻率、持續時間和硝痠甘油用量比較,差異均無統計學意義( P>0.05);治療後均顯著改善,且觀察組患者改善情況顯著優于對照組(P<0.05)。觀察組患者的心髒事件總髮生率(23.08%)顯著低于對照組(χ2=13.35,P<0.05);兩組患者治療前左心室前降支的血流參數之間沒有明顯差異(P>0.05),治療後均顯著升高,且觀察組顯著高于對照組(均P<0.05)。兩組患者用藥期間均未齣現明顯嚴重的不良癥狀。結論阿司匹林聯閤低分子右鏇糖酐治療急診梗死前心絞痛效果明顯,可降低心律失常、心肌梗死和心力衰竭的髮生率。
목적:평개아사필림연합저분자우선당항치료경사전심교통환자적림상료효,탐토기림상괄용성。방법78례경사전심교통환자간단수궤분위관찰조、대조조각39례,대조조환자채용상규치료,관찰조환자재차기출상채용아사필림합병저분자우선당항주사액치료。관찰병기록량조환자적심교통발작빈솔、지속시간、초산감유용량,용약기간적불량반응정황,처리결과화주요공혈관상동맥적혈류정황。결과치료전량조환자적심교통발작빈솔、지속시간화초산감유용량비교,차이균무통계학의의( P>0.05);치료후균현저개선,차관찰조환자개선정황현저우우대조조(P<0.05)。관찰조환자적심장사건총발생솔(23.08%)현저저우대조조(χ2=13.35,P<0.05);량조환자치료전좌심실전강지적혈류삼수지간몰유명현차이(P>0.05),치료후균현저승고,차관찰조현저고우대조조(균P<0.05)。량조환자용약기간균미출현명현엄중적불량증상。결론아사필림연합저분자우선당항치료급진경사전심교통효과명현,가강저심률실상、심기경사화심력쇠갈적발생솔。
Objective To evaluate the clinical efficacy of a combined medicine of aspirin and low molecular weight dextran in treating pre-infarction angina.Methods 78 cases of pre-infarction angina patients were randomly divided into an experimental group and a control group.The control group was treated with conventional therapy while the experimental group was treated with aspirin combined with low molecular dextran.The angina frequency, duration, adverse reactions, nitroglycerin consumption, coronary blood flow and medication of both groups were observed.Findings Before treatment, the differences in seizure frequency, duration and amount of nitroglycerin between the two groups were not statistically significant (P>0.05);after treatment, the differences were statistically significant (P<0.05).Those of the experimental group were better than those of the control group.The differences were statistically significant (P<0.05).The total heart incidence rate (23.08%) of the experimental group was lower than that of the control group of patients (64.10%).The difference was statistically significant.The flow parameters of descending branch of the left ventricle between the two groups of patients were not significantly different (P>0.05).The parameters in both groups were significantly improved after the treatment.The differences were statistically significant ( P<0.05) and the improvement of the experimental group was higher than that of the control group.The difference was statistically significant (P <0.05).There were no obvious symptoms of severe adverse drug as observed during the process of treatment.Conclusion The effect of aspirin combined with low molecular weight dextran as a medicine in treating pre-infarction angina is desirable.It can significantly reduce arrhythmia, myocardial infarction, and the incidence of mental exhaustion.