海南医学
海南醫學
해남의학
Hainan Medical Journal
2015年
20期
2985-2987
,共3页
急性冠状动脉综合征%GRACE评分%N-末端B型利钠肽原%冠脉动脉
急性冠狀動脈綜閤徵%GRACE評分%N-末耑B型利鈉肽原%冠脈動脈
급성관상동맥종합정%GRACE평분%N-말단B형리납태원%관맥동맥
Acute coronary syndrome%GRACE score%NT-proBNP%Coronary artery
目的 探讨非ST段抬高急性冠脉综合征(NSTE-ACS)患者全球急性冠状动脉事件注册(GRACE)评分和N-末端B型利钠肽原(NT-proBNP)水平与冠状动脉病变的关系,评价GRACE评分和NT-proBNP水平对NSTE-ACS患者冠状动脉病变的预测价值.方法 入选118例在我院住院的NSTE-ACS患者,入院后采用GRACE评分标准对患者进行危险评分,并测定患者血浆NT-proBNP浓度.行冠状动脉造影,采用Gensini评分系统评定冠状动脉狭窄程度.分析GRACE评分与冠脉病变(Gensini评分)的关系,NT-proBNP水平与Gensini评分的关系,并对GRACE评分与NT-proBNP水平的相关性进行分析.结果 随着GRACE危险评分危险程度和血浆NT-proBNP浓度的增加,NSTE-ACS冠脉的狭窄程度越严重(Gensini评分越高),各组间差异均具有统计学意义(P<0.05).GRACE危险评分与血浆NT-proBNP水平呈正相关(r=0.745).结论 GRACE评分与NT-proBNP检测都能在一定程度上反映患者冠脉病变程度,两者联合有助于早期更加快速准确地评估入院患者病情危重程度,对于指导NSTE-ACS患者的治疗和改善患者预后有重要意义.
目的 探討非ST段抬高急性冠脈綜閤徵(NSTE-ACS)患者全毬急性冠狀動脈事件註冊(GRACE)評分和N-末耑B型利鈉肽原(NT-proBNP)水平與冠狀動脈病變的關繫,評價GRACE評分和NT-proBNP水平對NSTE-ACS患者冠狀動脈病變的預測價值.方法 入選118例在我院住院的NSTE-ACS患者,入院後採用GRACE評分標準對患者進行危險評分,併測定患者血漿NT-proBNP濃度.行冠狀動脈造影,採用Gensini評分繫統評定冠狀動脈狹窄程度.分析GRACE評分與冠脈病變(Gensini評分)的關繫,NT-proBNP水平與Gensini評分的關繫,併對GRACE評分與NT-proBNP水平的相關性進行分析.結果 隨著GRACE危險評分危險程度和血漿NT-proBNP濃度的增加,NSTE-ACS冠脈的狹窄程度越嚴重(Gensini評分越高),各組間差異均具有統計學意義(P<0.05).GRACE危險評分與血漿NT-proBNP水平呈正相關(r=0.745).結論 GRACE評分與NT-proBNP檢測都能在一定程度上反映患者冠脈病變程度,兩者聯閤有助于早期更加快速準確地評估入院患者病情危重程度,對于指導NSTE-ACS患者的治療和改善患者預後有重要意義.
목적 탐토비ST단태고급성관맥종합정(NSTE-ACS)환자전구급성관상동맥사건주책(GRACE)평분화N-말단B형리납태원(NT-proBNP)수평여관상동맥병변적관계,평개GRACE평분화NT-proBNP수평대NSTE-ACS환자관상동맥병변적예측개치.방법 입선118례재아원주원적NSTE-ACS환자,입원후채용GRACE평분표준대환자진행위험평분,병측정환자혈장NT-proBNP농도.행관상동맥조영,채용Gensini평분계통평정관상동맥협착정도.분석GRACE평분여관맥병변(Gensini평분)적관계,NT-proBNP수평여Gensini평분적관계,병대GRACE평분여NT-proBNP수평적상관성진행분석.결과 수착GRACE위험평분위험정도화혈장NT-proBNP농도적증가,NSTE-ACS관맥적협착정도월엄중(Gensini평분월고),각조간차이균구유통계학의의(P<0.05).GRACE위험평분여혈장NT-proBNP수평정정상관(r=0.745).결론 GRACE평분여NT-proBNP검측도능재일정정도상반영환자관맥병변정도,량자연합유조우조기경가쾌속준학지평고입원환자병정위중정도,대우지도NSTE-ACS환자적치료화개선환자예후유중요의의.
Objective To study the relationship between GRACE risk score, N-terminal pro-brain natriuretic peptide (NT-proBNP) and pathological changes of coronary artery in patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS), and to assess the predictive value of GRACE risk score and NT-proBNP for patho-logical changes of coronary artery in NSTE-ACS patients. Methods A total of 118 NSTE-ACS inpatients from our hospital were enrolled in the study. GRACE risk score was used for risk assessment, and patients' plasma levels of NT-proBNP were measured. All patients were treated with coronary angiography, and then the severity of coronary ar-tery stenosis was assessed with Gensini scoring system. The correlations between GRACE score and Gensini score, NT-proBNP levels and Gensini score, and GRACE score and NT-proBNP levels were analyzed. Results The severi-ty of coronary stenosis increased along with the increase of GRACE risk score and plama NT-proBNP levels (P<0.05), and the GRACE risk score was positively related with NT-proBNP levels (r=0.745). Conclusion Both GRACE score and NT-proBNP can reflect the pathological changes of coronary artery. However, combination of the two can provide better and quicker assessment of patients' condition, which is therefore significant for the treatment and prognosis of NSTE-ACS.
