CAJ | 학술논문

肥胖与育龄期妇女生育能力的关系极为密切,尤其是以腹型肥胖者更加明显,此类人群多表现为月经稀发、雄激素水平增高及排卵障碍.此外,研究表明肥胖人群较正常人群更易发生多囊卵巢综合征、高雄激素血症和代谢功能异常.基础性激素水平紊乱可能是导致不同类型肥胖的关键因素之一,并且在大量研究中已证实降低体重可纠正性激素紊乱状态,降低雄激素水平,建立规律月经周期,恢复排卵,进而提高肥胖女性生育能力.以往针对此情况多采用二甲双胍等药物,通过改善胰岛素抵抗等途径增强卵巢功能,提供生育能力.近年来减肥药物因其具有减脂、改善胰岛素抵抗等作用,被用于此类患者的治疗,本文则对近年来多囊卵巢综合征与育龄期肥胖妇女生育能力及相关药物治疗进行综述.
비반여육령기부녀생육능력적관계겁위밀절,우기시이복형비반자경가명현,차류인군다표현위월경희발、웅격소수평증고급배란장애.차외,연구표명비반인군교정상인군경역발생다낭란소종합정、고웅격소혈증화대사공능이상.기출성격소수평문란가능시도치불동류형비반적관건인소지일,병차재대량연구중이증실강저체중가규정성격소문란상태,강저웅격소수평,건립규률월경주기,회복배란,진이제고비반녀성생육능력.이왕침대차정황다채용이갑쌍고등약물,통과개선이도소저항등도경증강란소공능,제공생육능력.근년래감비약물인기구유감지、개선이도소저항등작용,피용우차류환자적치료,본문칙대근년래다낭란소종합정여육령기비반부녀생육능력급상관약물치료진행종술.
The relationship between obesity and fertility in women of childbearing age is very close, especial-ly abdominal obesity. Females with obesity often show oligomenorrhea, increased androgen levels and ovulation obsta-cle. In addition, studies show that obese people are more likely to have polycystic ovary syndrome, hyperandrogen-emia and metabolic abnormalities, compared with normal people. Disorder in sex hormones levels may be one of the key factors causing obesity of different types. Studies have confirmed that reducing of weight can correct sex hormone disorder, reduce androgen levels, establish regular menstrual cycle and restore ovulation, and thus improve the fertility of obese females. Previous experience applied drugs such as metformin to strengthen the function of ovary and pro-mote fertility by improving insulin resistance. In recent years, anti-obesity drugs are used for the treatment because of its functions of reducing fat and improving insulin resistance. This paper reviews the recent progress in polycystic ova-ry syndrome, fertility of obese women in child-bearing age, and related drug therapies.