CAJ | 학술논문

胶质瘤是脑肿瘤中最常见的类型,其强大的侵袭力是一个非常棘手的临床问题,恶性肿瘤侵袭转移机制是肿瘤学研究的热点.小胶质细胞/脑巨噬细胞在胶质瘤的发展及侵袭过程中具有两方面作用,可以在胶质瘤微生态环境中通过胶质瘤分泌释放细胞因子调控促进胶质瘤的增生扩张,也能在人为作用影响下发挥肿瘤免疫作用.小胶质细胞/脑巨噬细胞透过血脑屏障改变肿瘤微生态环境使其表现为抑制胶质瘤侵袭扩张,将可能为胶质瘤的研究及治疗提供新思路和方法.
효질류시뇌종류중최상견적류형,기강대적침습력시일개비상극수적림상문제,악성종류침습전이궤제시종류학연구적열점.소효질세포/뇌거서세포재효질류적발전급침습과정중구유량방면작용,가이재효질류미생태배경중통과효질류분비석방세포인자조공촉진효질류적증생확장,야능재인위작용영향하발휘종류면역작용.소효질세포/뇌거서세포투과혈뇌병장개변종류미생태배경사기표현위억제효질류침습확장,장가능위효질류적연구급치료제공신사로화방법.
Glioma represents the most frequent type of human brain tumor, and its strong invasiveness is a sig-nificant clinical problem. Invasion and metastasis mechanism of malignant tumor is still a hot spot of oncological re-search. Microglia/brain macrophages have double effects on the expansion and invasion of glioma. On one hand, they can promote the expansion, invasion of glioma by release factor under the microenvironment of tumor. On the other hand, they can kill tumor cell in tumor immunity by the influence of human. Microglia/brain macrophages go cross the blood-brain barrier to change the glioma microenvironment and inhibit the expansion, invasion of glioma. The study of microglia/brain macrophages would provide new ideas and methods for research and treatment of gliomas.