CAJ | 학술논문

目的：制备芦丁-二甲基-β-环糊精（DM -β- CD）包合物，提高芦丁在水中的溶解度。方法采用相溶解度法进行增溶试验，绘制相溶解度曲线，计算包合稳定常数（K C ），利用研磨法制备芦丁-二甲基-β-环糊精包合物，以显微镜法、红外光谱法、体外溶出度法对包合物进行鉴定。结果芦丁与二甲基-β-环糊精相溶解度曲线属于 AN 型，在一定的二甲基-β-环糊精浓度范围内，芦丁的溶解度随着二甲基-β-环糊精浓度的增加呈线性增加，表明芦丁与二甲基-β-环糊精最佳包合比为1：1，在线性范围内计算包合稳定常数（KC ）为294.58 L·mol -1。结论芦丁与二甲基-β-环糊精包合后呈现了新的物相特征，表明芦丁-二甲基-β-环糊精包合物已经形成，且溶解度明显增高，研磨法制备芦丁-二甲基-β-环糊精包合物能明显提高芦丁的溶解度，此法可用于芦丁-二甲基-β-环糊精包合物的制备。
목적：제비호정-이갑기-β-배호정（DM -β- CD）포합물，제고호정재수중적용해도。방법채용상용해도법진행증용시험，회제상용해도곡선，계산포합은정상수（K C ），이용연마법제비호정-이갑기-β-배호정포합물，이현미경법、홍외광보법、체외용출도법대포합물진행감정。결과호정여이갑기-β-배호정상용해도곡선속우 AN 형，재일정적이갑기-β-배호정농도범위내，호정적용해도수착이갑기-β-배호정농도적증가정선성증가，표명호정여이갑기-β-배호정최가포합비위1：1，재선성범위내계산포합은정상수（KC ）위294.58 L·mol -1。결론호정여이갑기-β-배호정포합후정현료신적물상특정，표명호정-이갑기-β-배호정포합물이경형성，차용해도명현증고，연마법제비호정-이갑기-β-배호정포합물능명현제고호정적용해도，차법가용우호정-이갑기-β-배호정포합물적제비。
Objective To prepare the rutin - DM - β - CD inclusion complex and elevate the solubilization capacity of DM - β - CD for rutin. Methods Phase solubility method was used to perform a soluble experiment of rutin,drew phase solubility curves and calculated the inclusion stability constant(KC ). The characteristic of rutin - DM - β - CD inclusion complex was identified by microscopy,FT - IR and dissolution etc. Results Phase solubility curves of rutin in DM - β -CD belong to typical AN. In a certain DM - β - CD concentration range,the solubility of rutin increased linearly as DM - β- CD concentration. Phase solubility profile showed that the molar ratio of rutin and DM - β - CD was 1:1. The stability constant of rutin - DM - β - CD was 294. 58 L·mol - 1 . Conclusion Rutin was complexed in DM - β - CD,which pres-ents new phase characteristics. It indicated that the inclusion complex was formed and the solubility of rutin was improved significantly. It was a good method to prepare rutin - DM - β - CD inclusion complex.