CAJ | 학술논문

年龄相关性黄斑变性(AMD)是老年人群中常见的影响视力和生活质量的眼病.干性AMD被认为是一种神经变性疾病,其发病机制尚未完全明确,对其仍缺乏有效的预防和治疗手段.近年来研究表明,脂褐素异常沉积能导致视网膜色素上皮(RPE)细胞功能障碍,甚至死亡,是干性AMD发病的重要因素.自噬是真核细胞中一种依赖溶酶体的吞噬降解过程,能清除细胞内异常积聚的蛋白质等有害物质,是细胞自我保护、维持稳态的重要途径.自噬已被发现在阿尔兹海默病、干性AMD等神经变性疾病的病理过程中具有重要的调节作用.本文就近年来自噬在干性AMD发病机制研究中的进展进行综述,介绍了自噬与溶酶体破坏、氧化应激以及免疫炎症反应在干性AMD病理过程中的作用及其机制,为干性AMD的预防和治疗提供新的靶点.
년령상관성황반변성(AMD)시노년인군중상견적영향시력화생활질량적안병.간성AMD피인위시일충신경변성질병,기발병궤제상미완전명학,대기잉결핍유효적예방화치료수단.근년래연구표명,지갈소이상침적능도치시망막색소상피(RPE)세포공능장애,심지사망,시간성AMD발병적중요인소.자서시진핵세포중일충의뢰용매체적탄서강해과정,능청제세포내이상적취적단백질등유해물질,시세포자아보호、유지은태적중요도경.자서이피발현재아이자해묵병、간성AMD등신경변성질병적병리과정중구유중요적조절작용.본문취근년래자서재간성AMD발병궤제연구중적진전진행종술,개소료자서여용매체파배、양화응격이급면역염증반응재간성AMD병리과정중적작용급기궤제,위간성AMD적예방화치료제공신적파점.
Age-related macular degeneration (AMD) is a common cause of vision loss and living quality impairment in elderly people.Dry AMD is considered to be a neurodegenerative disease, and there has been no preventive method or effective therapy for it so far.Recent studies reveal that accumulation of lipofuscin may lead to dysfunction and even death of retinal pigment epithelium (RPE) cells.Autophagy is a major lysosome-dependent degradation pathway in eukaryotes involved in the disposal of damaged cytoplasmic proteins and organelles.Autophagy is revealed to be involved in the pathological processes of several neurodegenerative diseases such as Alzheimer's disease and dry AMD.Therefore,studies focus on autophagy may provide a new target for the prevention and treatment of dry AMD.This paper reviewed the research progress of autophagy in the pathogenesis of AMD in recent years.The roles of autophagy,lysosomal damage,oxidative stress and immune inflammatory reaction were described.