CAJ | 학술논문

氧化应激诱导的神经细胞凋亡，在神经退行性疾病的发生及发展过程中发挥重要作用，其调控途径主要包括NF-κB通路、p53通路、MAPK通路、PI3K／Akt通路、Nrf2通路等信号通路。大量文献报道，中药有效成分具有显著抑制氧化应激诱导的神经细胞凋亡的生物活性。本文综述近5年来中药有效成分抑制氧化应激诱导的神经细胞凋亡的相关机制研究进展，以期为阐释中药有效成分防治神经退行性疾病的作用机制，更有效地防治神经退行性疾病提供参考依据和线索。
양화응격유도적신경세포조망，재신경퇴행성질병적발생급발전과정중발휘중요작용，기조공도경주요포괄NF-κB통로、p53통로、MAPK통로、PI3K／Akt통로、Nrf2통로등신호통로。대량문헌보도，중약유효성분구유현저억제양화응격유도적신경세포조망적생물활성。본문종술근5년래중약유효성분억제양화응격유도적신경세포조망적상관궤제연구진전，이기위천석중약유효성분방치신경퇴행성질병적작용궤제，경유효지방치신경퇴행성질병제공삼고의거화선색。
Oxidative stress-induced neuronal apoptosis plays a vital role in the development of neurodegenerative disorders;while at present its regulation pathways mainly include the NF-κB pathway;p53 pathway;MAPK path-way;PI3 K/Akt pathway;Nrf2 pathway;as well as other signaling pathways.Research findings suggest that the active components in Chinese materia medica exert significant biological activities in the treatment of oxidative stress-induced neuronal apoptosis.In the present paper;we review the recent research advances on the relative mechanisms of active components in Chinese materia medica against oxidative stress-induced neuronal apoptosis;so as to provide some references or clues for the clarification of possible mechanisms of active components in Chinese materia medica and the treatment of related neurodegenerative diseases.