中国药科大学学报
中國藥科大學學報
중국약과대학학보
Journal of China Pharmaceutical University
2015年
5期
513-520
,共8页
贺威%齐海霞%董磊%张峻峰
賀威%齊海霞%董磊%張峻峰
하위%제해하%동뢰%장준봉
靶向药物输送系统%免疫系统%免疫细胞%免疫器官%主动靶向%被动靶向
靶嚮藥物輸送繫統%免疫繫統%免疫細胞%免疫器官%主動靶嚮%被動靶嚮
파향약물수송계통%면역계통%면역세포%면역기관%주동파향%피동파향
targeting drug delivery%immune system%immune cells%immune organs%active targeting%passive tar-geting
靶向免疫系统的递药系统在治疗炎症性疾病中发挥着重要作用。靶向免疫系统的递药系统可靶向免疫细胞或免疫器官，分为由配体-受体和抗原-抗体介导的主动靶向以及pH、颗粒介导的被动靶向。本文针对上述分类，综述了近年来靶向免疫系统的递药系统的新进展，为设计安全有效的靶向免疫细胞或免疫器官的递药系统、以及对炎症性疾病的高效安全治疗提供理论参考。
靶嚮免疫繫統的遞藥繫統在治療炎癥性疾病中髮揮著重要作用。靶嚮免疫繫統的遞藥繫統可靶嚮免疫細胞或免疫器官，分為由配體-受體和抗原-抗體介導的主動靶嚮以及pH、顆粒介導的被動靶嚮。本文針對上述分類，綜述瞭近年來靶嚮免疫繫統的遞藥繫統的新進展，為設計安全有效的靶嚮免疫細胞或免疫器官的遞藥繫統、以及對炎癥性疾病的高效安全治療提供理論參攷。
파향면역계통적체약계통재치료염증성질병중발휘착중요작용。파향면역계통적체약계통가파향면역세포혹면역기관，분위유배체-수체화항원-항체개도적주동파향이급pH、과립개도적피동파향。본문침대상술분류，종술료근년래파향면역계통적체약계통적신진전，위설계안전유효적파향면역세포혹면역기관적체약계통、이급대염증성질병적고효안전치료제공이론삼고。
Drug delivery system targeting immune system plays an important role in the treatment of inflammatory diseases.Drug delivery system targeting immune system could target immune cells or immune organs.It could be divided into active targeting mediated by the interaction of ligand-receptor or antigen-antibody and passive targe-ting mediated by pH;particles and so on.This review summarizes new progress for drug delivery system targeting immune system;which provides a theoretical reference for designing the safe and effective drug delivery system and providing efficient and safe treatment for inflammatory diseases.
