山东医药
山東醫藥
산동의약
Shandong Medical Journal
2015年
39期
13-15
,共3页
2型糖尿病%叉头转录因子O3 a%基因多态性
2型糖尿病%扠頭轉錄因子O3 a%基因多態性
2형당뇨병%차두전록인자O3 a%기인다태성
diabetes mellitus,type 2%forkhead box class O3a%gene polymorphisms
目的：观察辽宁地区2型糖尿病患者FoxO3a基因rs2253310位点多态性，探讨rs2253310多态性与2型糖尿病的相关性。方法纳入2型糖尿病患者374例（病例组），非糖尿病健康志愿者283例（对照组）。检测并比较两组FoxO3a基因rs2253310单核苷酸多态性。测算不同rs2253310基因型患者的BMI，测量收缩压（SBP）、舒张压（DBP）、空腹血糖（FBG）。结果病例组BMI、SBP、DBP、FBG高于对照组（P均＜0．05）。两组FoxO3a基因rs2253310基因型GG纯合子为主，等位基因以G基因为主；病例组rs2253310位点G等位基因频率为73．4％、GG基因型频率为54．01％，对照组分别为74．56％、55．12％，两组相比，P均＞0．05。病例组中不同rs2253310基因型患者BMI、SBP、DBP、FBG差异无统计学意义。结论 FoxO3a基因rs2253310位点多态性与2型糖尿病无相关性。
目的：觀察遼寧地區2型糖尿病患者FoxO3a基因rs2253310位點多態性，探討rs2253310多態性與2型糖尿病的相關性。方法納入2型糖尿病患者374例（病例組），非糖尿病健康誌願者283例（對照組）。檢測併比較兩組FoxO3a基因rs2253310單覈苷痠多態性。測算不同rs2253310基因型患者的BMI，測量收縮壓（SBP）、舒張壓（DBP）、空腹血糖（FBG）。結果病例組BMI、SBP、DBP、FBG高于對照組（P均＜0．05）。兩組FoxO3a基因rs2253310基因型GG純閤子為主，等位基因以G基因為主；病例組rs2253310位點G等位基因頻率為73．4％、GG基因型頻率為54．01％，對照組分彆為74．56％、55．12％，兩組相比，P均＞0．05。病例組中不同rs2253310基因型患者BMI、SBP、DBP、FBG差異無統計學意義。結論 FoxO3a基因rs2253310位點多態性與2型糖尿病無相關性。
목적：관찰료녕지구2형당뇨병환자FoxO3a기인rs2253310위점다태성，탐토rs2253310다태성여2형당뇨병적상관성。방법납입2형당뇨병환자374례（병례조），비당뇨병건강지원자283례（대조조）。검측병비교량조FoxO3a기인rs2253310단핵감산다태성。측산불동rs2253310기인형환자적BMI，측량수축압（SBP）、서장압（DBP）、공복혈당（FBG）。결과병례조BMI、SBP、DBP、FBG고우대조조（P균＜0．05）。량조FoxO3a기인rs2253310기인형GG순합자위주，등위기인이G기인위주；병례조rs2253310위점G등위기인빈솔위73．4％、GG기인형빈솔위54．01％，대조조분별위74．56％、55．12％，량조상비，P균＞0．05。병례조중불동rs2253310기인형환자BMI、SBP、DBP、FBG차이무통계학의의。결론 FoxO3a기인rs2253310위점다태성여2형당뇨병무상관성。
Objective To observe the gene polymorphisms of rs 2253310 in FoxO3a of patients with type 2 diabetes mellitus in Liaoning , and to investigate the relationship between the gene polymorphism of rs 2253310 and type 2 diabetes mellitus.Methods The single nucleotides polymorphism of rs 2253310 in FoxO3a of 374 cases of patients with type 2 dia-betes mellitus ( experimental group ) were detected and 283 cases of control subjects without diabetes ( control group ) .We measured the body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP) and fasting blood glucose (FBG) of different rs2253310 genotypes in patients.Results BMI, SBP, DBP and FBG in the experimental group were significantly higher than those of the control group (all P<0.05).The homozygous genotype GG was the most genotype and G gene was the most allele in FoxO 3a gene rs2253310 of the two groups .The G allele frequency and the GG genotype frequency in the experimental group were 73.4%and 54.01%, while in the control group they were 74.56%and 55.12%; there was no statistically significant difference between the two groups (all P >0.05).In the experimental group, there was no statistically significant difference in BMI , SBP, DBP and FBG in the different genotypes of rs 2253310 . Conclusion The single nucleotide polymorphisms of rs 2253310 in FoxO3a was not associated with type 2 diabetes melli-tus.
