CAJ | 학술논문

目的：探讨微炎性反应状态与慢性肾脏病（ CKD ）的相关性。方法2013年12月—2014年8月调查新疆墨玉县维吾尔族人群3418名，其中CKD患者198例，作为CKD组；健康体检者1512名，随机抽取194名为健康对照组。对所有的研究对象进行常规体检、问卷调查及检测IL-6、TNF-α、TGF-β、hs-CRP等炎性指标。结果 CKD组体质量、腰围、臀围、TG、TC、DBP、SBP、BMI均大于健康对照组，差异有统计学意义（ P均＜0．05），eGFR低于健康对照组（ P ＜0．05）。 CKD组IL-6、hs-CRP、TNF-α、TGF-β水平均高于健康对照组，差异均有统计学意义（ P均＜0．05）。相关性分析表明，CKD组患者eGFR与IL-6、体质量、BMI均呈负相关（ B ＝－0．802、－1．540、－3．688， P ＜0．05）。结论 hs-CRP、IL-6、TNF-α、TGF-β等炎性因子可能参与慢性肾脏病的发生与进展，因此临床中除控制体质量、改善代谢、控制血压，监测并减轻患者体内微炎性程度水平对改善CKD预后同样有重要意义。
목적：탐토미염성반응상태여만성신장병（ CKD ）적상관성。방법2013년12월—2014년8월조사신강묵옥현유오이족인군3418명，기중CKD환자198례，작위CKD조；건강체검자1512명，수궤추취194명위건강대조조。대소유적연구대상진행상규체검、문권조사급검측IL-6、TNF-α、TGF-β、hs-CRP등염성지표。결과 CKD조체질량、요위、둔위、TG、TC、DBP、SBP、BMI균대우건강대조조，차이유통계학의의（ P균＜0．05），eGFR저우건강대조조（ P ＜0．05）。 CKD조IL-6、hs-CRP、TNF-α、TGF-β수평균고우건강대조조，차이균유통계학의의（ P균＜0．05）。상관성분석표명，CKD조환자eGFR여IL-6、체질량、BMI균정부상관（ B ＝－0．802、－1．540、－3．688， P ＜0．05）。결론 hs-CRP、IL-6、TNF-α、TGF-β등염성인자가능삼여만성신장병적발생여진전，인차림상중제공제체질량、개선대사、공제혈압，감측병감경환자체내미염성정도수평대개선CKD예후동양유중요의의。
Objective To investigate the relationship between the state of inflammation and chronic kidney disease (CKD).Methods From December 2013 to August 2014, investigated population of Moyu County in Xinjiang Uygur ( n =3 418) , including 198 cases of patients with CKD,as the CKD group;health examination of 1 512 cases, and randomly se-lected 194 healthy cases from them as the control group.Routine examination of all subjects, questionnaire survey and deter-mination of IL-6 and TNF-alpha, TGF-beta, hs-CRP inflammatory markers were performed.Results In the CKD group, body mass, waist circumference, hip circumference, TG, TC, DBP, SBP, BMI were higher than those of healthy control group, the difference was statistically significant ( P <0.05),eGFR was lower than that of the normal control group ( P <0.05). CKD group’ s IL-6, hs-CRP, TNF-alpha, TGF-beta level were higher than those in healthy control group, the differences were statistically significant ( P <0.05).Correlation analysis showed that eGFR was negatively correlated with IL-6,body weight and BMI in CKD group( B =-0.082,-1.540,3.688, P <0.05).Conclusion The levels of serum hs-CRP, IL-6 and TNF-alpha, TGF-beta and inflammatory cytokines may be involved in the occurrence and development of chronic kidney dis-ease, so control body weight, improve metabolism, control blood pressure, monitor and mitigate micro inflammatory level to improve the prognosis of patients with CKD also has important significance.