疑难病杂志
疑難病雜誌
의난병잡지
Chinese Journal of Difficult and Complicated Cases
2015年
11期
1118-1121
,共4页
范瑞华%张铁成%姚榕%黄明德
範瑞華%張鐵成%姚榕%黃明德
범서화%장철성%요용%황명덕
食管癌%适形放疗%同步放化疗
食管癌%適形放療%同步放化療
식관암%괄형방료%동보방화료
Esophageal cancer%Conformal radiotherapy%Concurrent chemo-radiotherapy
目的：观察三维适形放疗联合小剂量TP （多西他赛＋顺铂）化疗对食管癌患者的近期疗效和安全性。方法晚期食管癌患者56例随机分为观察组和对照组各28例。观察组予以三维适形放疗联合小剂量TP化疗，对照组予以三维适形放疗。对比2组患者治疗前后临床症状积分、近期疗效、不良反应发生率和生活质量评分（卡氏评分）。结果2组患者治疗后的声音嘶哑、进食梗阻和饮水呛咳积分均显著低于治疗前（ P ＜0厖．05），且观察组声音显著低于对照组（ P ＜0．05）。观察组近期缓解率为89．28％，高于对照组的42．86％（ P ＜0．05）。观察组患者的放射性食管炎、恶心呕吐和骨髓抑制总发生率分别为60．72％、25．00％和64．29％，对照组患者分别为53．57％、28．57％和60．71％，2组比较差异无统计学意义（ P ＜0．05）。2组患者治疗后的卡氏评分显著高于治疗前[观察组为（75．64±2．36）分vs．（82．09±3．39）分，对照组为（74．60±2．63）分vs．（78．27±3．01）分， P ＜0．05]，且治疗后观察组的卡氏评分显著高于对照组（ P ＜0．05）。结论小剂量多西他赛与顺铂化疗联合三维适形放疗治疗食管癌患者是安全、有效的。
目的：觀察三維適形放療聯閤小劑量TP （多西他賽＋順鉑）化療對食管癌患者的近期療效和安全性。方法晚期食管癌患者56例隨機分為觀察組和對照組各28例。觀察組予以三維適形放療聯閤小劑量TP化療，對照組予以三維適形放療。對比2組患者治療前後臨床癥狀積分、近期療效、不良反應髮生率和生活質量評分（卡氏評分）。結果2組患者治療後的聲音嘶啞、進食梗阻和飲水嗆咳積分均顯著低于治療前（ P ＜0厖．05），且觀察組聲音顯著低于對照組（ P ＜0．05）。觀察組近期緩解率為89．28％，高于對照組的42．86％（ P ＜0．05）。觀察組患者的放射性食管炎、噁心嘔吐和骨髓抑製總髮生率分彆為60．72％、25．00％和64．29％，對照組患者分彆為53．57％、28．57％和60．71％，2組比較差異無統計學意義（ P ＜0．05）。2組患者治療後的卡氏評分顯著高于治療前[觀察組為（75．64±2．36）分vs．（82．09±3．39）分，對照組為（74．60±2．63）分vs．（78．27±3．01）分， P ＜0．05]，且治療後觀察組的卡氏評分顯著高于對照組（ P ＜0．05）。結論小劑量多西他賽與順鉑化療聯閤三維適形放療治療食管癌患者是安全、有效的。
목적：관찰삼유괄형방료연합소제량TP （다서타새＋순박）화료대식관암환자적근기료효화안전성。방법만기식관암환자56례수궤분위관찰조화대조조각28례。관찰조여이삼유괄형방료연합소제량TP화료，대조조여이삼유괄형방료。대비2조환자치료전후림상증상적분、근기료효、불량반응발생솔화생활질량평분（잡씨평분）。결과2조환자치료후적성음시아、진식경조화음수창해적분균현저저우치료전（ P ＜0방．05），차관찰조성음현저저우대조조（ P ＜0．05）。관찰조근기완해솔위89．28％，고우대조조적42．86％（ P ＜0．05）。관찰조환자적방사성식관염、악심구토화골수억제총발생솔분별위60．72％、25．00％화64．29％，대조조환자분별위53．57％、28．57％화60．71％，2조비교차이무통계학의의（ P ＜0．05）。2조환자치료후적잡씨평분현저고우치료전[관찰조위（75．64±2．36）분vs．（82．09±3．39）분，대조조위（74．60±2．63）분vs．（78．27±3．01）분， P ＜0．05]，차치료후관찰조적잡씨평분현저고우대조조（ P ＜0．05）。결론소제량다서타새여순박화료연합삼유괄형방료치료식관암환자시안전、유효적。
Objective To observe the short term efficacy and safety of three-dimensional conformal radiotherapy com-bined with small dose of TP ( docetaxel +cisplatin) chemotherapy for patients with esophageal cancer.Methods 56 cases of esophageal cancer patients were randomly divided into observation group and control group with 28 cases in each group.Three dimensional conformal radiotherapy combined with low-dose TP chemotherapy were performed in the observation group, and the control group was treated with three-dimensional conformal radiotherapy.The clinical symptom score, the short-term effica-cy, the incidence of adverse reactions and the quality of life score were compared between the 2 groups before and after treat-ment.Results After treatment, the patients in both of the two groups’ hoarseness, eating obstruction and drinking cough score were significantly lower than those before treatment ( P <0.05), and the observation group’s hoarseness was signifi-cantly lower than that of control group ( P <0.05).The observation group’ s short term improvement rate was 89.28%, which was higher than 42.86%in the control group ( P <0.05).Observation group patients’ radiation-induced esophageal inflammation, nausea and vomiting, bone marrow inhibited total incidence rate were 60.72% and 25.00% and 64.29% re-spectively, the control group patients were 53.57%, 28.57%, 60.71%respectively, the difference between the 2 groups did not show statistically significant ( P <0.05) .Karnofsky score of the two groups after treatment was significantly higher than that of before treatment (75.64 ±2.36) points vs.(82.09 ±3.39) points, (74.60 ±2.63) points vs.(78.27 ±3.01) points, respectively, P <0.05) and after treatment observation group’s Karnofsky score was significantly higher than that of the control group ( P <0.05).Conclusion Low dose of docetaxel and cisplatin chemotherapy combined with three-dimen-sional conformal radiotherapy for patients with esophageal cancer is safe and effective.
