疑难病杂志
疑難病雜誌
의난병잡지
Chinese Journal of Difficult and Complicated Cases
2015年
11期
1111-1114
,共4页
杨西爱%龚家明%刘毅%赵雪%胡德蓉
楊西愛%龔傢明%劉毅%趙雪%鬍德蓉
양서애%공가명%류의%조설%호덕용
脑梗死,急性%低密度脂蛋白胆固醇%同型半胱氨酸%新蝶呤%C反应蛋白%内膜中层厚度
腦梗死,急性%低密度脂蛋白膽固醇%同型半胱氨痠%新蝶呤%C反應蛋白%內膜中層厚度
뇌경사,급성%저밀도지단백담고순%동형반광안산%신접령%C반응단백%내막중층후도
Cerebral infarction,acute%Low density lipoprotein cholesterol%Homocysteine%Neopterin%C reactive pro-tein%Intima-media thickness
目的:探讨急性脑梗死( ACI)患者低密度脂蛋白胆固醇( LDL-C)、同型半胱氨酸( Hcy)、新蝶呤( Npt)、C反应蛋白( CRP)水平的改变及其与颈动脉粥样硬化的关系。方法2014年6月—2015年6月诊治ACI死患者68例为ACI组,选取同期行健康检查的体检者60例为健康对照组,应用多普勒超声仪测定2组颈动脉内膜中层厚度( IMT),ELISA法测定2组血浆Hcy、Npt,酶直接法测定血浆LDL-C,乳胶免疫比浊法测定CRP。结果 ACI组患者颈动脉斑块发生率为91潩.17%,显著高于健康对照组10.00%( P <0.05);ACI组血浆LDL-C(4.98±0.89)mmol/L、Hcy(38.96±4.89)μmol/L、Npt(2.45±0.48) ng/ml、CRP(6.89±0.48) mg/L水平高于健康对照组(2.86±0.93) mmol/L、(18.02±3.88)μmol/L、(1.38±0.59)ng/ml、(1.58±0.56)mg/L( P <0.05),而颈动脉IMT(1.85±0.32) mm大于健康对照组(0.42±0.16),差异均有统计学意义( P <0.05)。 ACI患者中软斑亚组、混合斑亚组血浆LDL-C、Hcy、Npt、CRP水平显著高于硬斑亚组( P <0.05)。经Pearson单因素分析,血浆LDL-C、Hcy、Npt、CRP水平与IMT呈正相关( r =0.412、0.326、0.345、0.369, P <0.05)。结论 ACI合并颈动脉不稳定斑块患者血浆LDL-C、Hcy、Npt、CRP水平显著高于斑块不稳定患者,提示血浆LDL-C、Hcy、Npt、CRP水平可反映ACI患者颈动脉粥样硬化稳定性。
目的:探討急性腦梗死( ACI)患者低密度脂蛋白膽固醇( LDL-C)、同型半胱氨痠( Hcy)、新蝶呤( Npt)、C反應蛋白( CRP)水平的改變及其與頸動脈粥樣硬化的關繫。方法2014年6月—2015年6月診治ACI死患者68例為ACI組,選取同期行健康檢查的體檢者60例為健康對照組,應用多普勒超聲儀測定2組頸動脈內膜中層厚度( IMT),ELISA法測定2組血漿Hcy、Npt,酶直接法測定血漿LDL-C,乳膠免疫比濁法測定CRP。結果 ACI組患者頸動脈斑塊髮生率為91潩.17%,顯著高于健康對照組10.00%( P <0.05);ACI組血漿LDL-C(4.98±0.89)mmol/L、Hcy(38.96±4.89)μmol/L、Npt(2.45±0.48) ng/ml、CRP(6.89±0.48) mg/L水平高于健康對照組(2.86±0.93) mmol/L、(18.02±3.88)μmol/L、(1.38±0.59)ng/ml、(1.58±0.56)mg/L( P <0.05),而頸動脈IMT(1.85±0.32) mm大于健康對照組(0.42±0.16),差異均有統計學意義( P <0.05)。 ACI患者中軟斑亞組、混閤斑亞組血漿LDL-C、Hcy、Npt、CRP水平顯著高于硬斑亞組( P <0.05)。經Pearson單因素分析,血漿LDL-C、Hcy、Npt、CRP水平與IMT呈正相關( r =0.412、0.326、0.345、0.369, P <0.05)。結論 ACI閤併頸動脈不穩定斑塊患者血漿LDL-C、Hcy、Npt、CRP水平顯著高于斑塊不穩定患者,提示血漿LDL-C、Hcy、Npt、CRP水平可反映ACI患者頸動脈粥樣硬化穩定性。
목적:탐토급성뇌경사( ACI)환자저밀도지단백담고순( LDL-C)、동형반광안산( Hcy)、신접령( Npt)、C반응단백( CRP)수평적개변급기여경동맥죽양경화적관계。방법2014년6월—2015년6월진치ACI사환자68례위ACI조,선취동기행건강검사적체검자60례위건강대조조,응용다보륵초성의측정2조경동맥내막중층후도( IMT),ELISA법측정2조혈장Hcy、Npt,매직접법측정혈장LDL-C,유효면역비탁법측정CRP。결과 ACI조환자경동맥반괴발생솔위91이.17%,현저고우건강대조조10.00%( P <0.05);ACI조혈장LDL-C(4.98±0.89)mmol/L、Hcy(38.96±4.89)μmol/L、Npt(2.45±0.48) ng/ml、CRP(6.89±0.48) mg/L수평고우건강대조조(2.86±0.93) mmol/L、(18.02±3.88)μmol/L、(1.38±0.59)ng/ml、(1.58±0.56)mg/L( P <0.05),이경동맥IMT(1.85±0.32) mm대우건강대조조(0.42±0.16),차이균유통계학의의( P <0.05)。 ACI환자중연반아조、혼합반아조혈장LDL-C、Hcy、Npt、CRP수평현저고우경반아조( P <0.05)。경Pearson단인소분석,혈장LDL-C、Hcy、Npt、CRP수평여IMT정정상관( r =0.412、0.326、0.345、0.369, P <0.05)。결론 ACI합병경동맥불은정반괴환자혈장LDL-C、Hcy、Npt、CRP수평현저고우반괴불은정환자,제시혈장LDL-C、Hcy、Npt、CRP수평가반영ACI환자경동맥죽양경화은정성。
Objective To investigate acute cerebral infarction ( ACI) patients of low density lipoprotein cholesterol (LDL-C), homocysteine (Hcy) and neopterin (Npt), C-reactive protein (CRP) levels and their relationships with carotid atherosclerosis.Methods From June 2014 to June 2015, 68 cases of ACI dead patients as ACI group, selected the same pe-riod in the hospital for health examination's 60 cases of healthy control as control group, two groups of carotid artery intima-media thickness ( IMT) by Doppler ultrasound were measured, ELISA method were used for the determination of 2 groups'plasma Hcy and Npt, direct enzymatic were used to measure plasma LDL-C, immuno latex turbidimetric method were used to measure CRP.Results ACI patients'carotid artery plaque incidence rate was 91.17%, significantly higher than that in the healthy control group (10.00%, P <0.05), ACI group's the plasma level of LDL-C was (4.98 ±0.89) mmol/L, Hcy was (38.96 ±4.89) mol/L Npt was (2.45 ±0.48) ng/ml, CRP was (6.89 ±0.48) mg/L, which were higher than that in the healthy control group (2.86 ±0.93) mmol/L, (18.02 ±3.88) μmol/L, (1.38 ±0.59) ng/ml, (1.58 ±0.56) mg/L, and carotid artery IMT (1.85 ±0.32) mm was greater than that in the healthy control group (0.42 ±0.16) mm, the differences were statistically significant ( P <0.05).ACI patients'soft spot subgroups, mixed plaque subgroups'plasma LDL-C, Hcy, Npt and CRP levels were significantly higher than those of the hard plaque subgroups ( P <0.05).By Pearson univariate analysis, plasma LDL-C, Hcy, Npt, CRP and IMT was positively correlated ( r =0.412, r =0.326, r =0.345, r =0.369, P <0.05).Conclusion ACI with Carotid plaque instability of plasma LDL-C, Hcy, Npt, CRP levels were significantly higher than the unstable plaque group, suggesting that plasma LDL-C, Hcy, Npt, CRP levels may reflect the level of the ca-rotid artery in patients with ACI atherosclerosis stability.