CAJ | 학술논문

目的：探讨阿奇霉素联合芩百清肺浓缩丸对儿童肺炎支原体感染的临床疗效。方法2013年1月—2014年6月收治肺炎支原体感染患儿156例，随机分为3组：中药组、西药组、联合组，每组52例。选择同期52例健康体检儿童为健康对照组，西药组口服阿奇霉素，中药组口服芩百清肺浓缩丸，联合组口服阿奇霉素联合芩百清肺浓缩丸。比较4组血清炎性因子（ IL-6、IL-8、TNF-α、）和免疫球蛋白（ IgA 、IgG、IgM）水平。结果治疗2周后，联合组、西药组和中药组有效率分别为98灋．1％（51／52）、84．6％（44／52）、90．4％（47／52），联合组高于西药组、中药组，差异有统计学意义（ P ＜0．05）。与联合组比较，西药组、中药组的咳嗽消失时间、发热消失时间、肺部啰音消失时间、X线胸片浸润影消失时间和住院时间，差异均有统计学意义（ P ＜0．05），而西药组与中药组比较，差异无统计学意义（ P ＞0．05）。治疗前，3个病例组患儿血清炎性因子水平（IL-6、IL-8、TNF-α）明显高于健康对照组（ P ＜0．05）；与治疗前比较，治疗2周后，3组血清炎性因子水平均显著降低（ P ＜0．05）；且治疗后联合组血清炎性因子水平均显著低于西药组和中药组（ P ＜0．05），西药组与中药组比较差异无统计学意义（ P ＞0．05）。治疗前，3个病例组患儿IgA水平显著低于健康对照组，IgG、IgM水平明显高于健康对照组（ P ＜0．05）；与治疗前比较，治疗2周后，3组IgA水平显著增加，IgG、IgM水平明显降低（ P ＜0．05）；且联合组IgA水平明显高于西药组和中药组，IgG、IgM水平显著低于西药组和中药组（ P ＜0．05），西药组与中药组比较差异无统计学意义（ P ＞0．05）。结论芩百清肺浓缩丸联合阿奇霉素治疗儿童肺炎支原体肺炎可降低细胞炎性因子水平、改善免疫功能可较好地改善病情，提高疗效。目的：探討阿奇黴素聯閤芩百清肺濃縮汍對兒童肺炎支原體感染的臨床療效。方法2013年1月—2014年6月收治肺炎支原體感染患兒156例，隨機分為3組：中藥組、西藥組、聯閤組，每組52例。選擇同期52例健康體檢兒童為健康對照組，西藥組口服阿奇黴素，中藥組口服芩百清肺濃縮汍，聯閤組口服阿奇黴素聯閤芩百清肺濃縮汍。比較4組血清炎性因子（ IL-6、IL-8、TNF-α、）和免疫毬蛋白（ IgA 、IgG、IgM）水平。結果治療2週後，聯閤組、西藥組和中藥組有效率分彆為98灋．1％（51／52）、84．6％（44／52）、90．4％（47／52），聯閤組高于西藥組、中藥組，差異有統計學意義（ P ＜0．05）。與聯閤組比較，西藥組、中藥組的咳嗽消失時間、髮熱消失時間、肺部啰音消失時間、X線胸片浸潤影消失時間和住院時間，差異均有統計學意義（ P ＜0．05），而西藥組與中藥組比較，差異無統計學意義（ P ＞0．05）。治療前，3箇病例組患兒血清炎性因子水平（IL-6、IL-8、TNF-α）明顯高于健康對照組（ P ＜0．05）；與治療前比較，治療2週後，3組血清炎性因子水平均顯著降低（ P ＜0．05）；且治療後聯閤組血清炎性因子水平均顯著低于西藥組和中藥組（ P ＜0．05），西藥組與中藥組比較差異無統計學意義（ P ＞0．05）。治療前，3箇病例組患兒IgA水平顯著低于健康對照組，IgG、IgM水平明顯高于健康對照組（ P ＜0．05）；與治療前比較，治療2週後，3組IgA水平顯著增加，IgG、IgM水平明顯降低（ P ＜0．05）；且聯閤組IgA水平明顯高于西藥組和中藥組，IgG、IgM水平顯著低于西藥組和中藥組（ P ＜0．05），西藥組與中藥組比較差異無統計學意義（ P ＞0．05）。結論芩百清肺濃縮汍聯閤阿奇黴素治療兒童肺炎支原體肺炎可降低細胞炎性因子水平、改善免疫功能可較好地改善病情，提高療效。
목적：탐토아기매소연합금백청폐농축환대인동폐염지원체감염적림상료효。방법2013년1월—2014년6월수치폐염지원체감염환인156례，수궤분위3조：중약조、서약조、연합조，매조52례。선택동기52례건강체검인동위건강대조조，서약조구복아기매소，중약조구복금백청폐농축환，연합조구복아기매소연합금백청폐농축환。비교4조혈청염성인자（ IL-6、IL-8、TNF-α、）화면역구단백（ IgA 、IgG、IgM）수평。결과치료2주후，연합조、서약조화중약조유효솔분별위98법．1％（51／52）、84．6％（44／52）、90．4％（47／52），연합조고우서약조、중약조，차이유통계학의의（ P ＜0．05）。여연합조비교，서약조、중약조적해수소실시간、발열소실시간、폐부라음소실시간、X선흉편침윤영소실시간화주원시간，차이균유통계학의의（ P ＜0．05），이서약조여중약조비교，차이무통계학의의（ P ＞0．05）。치료전，3개병례조환인혈청염성인자수평（IL-6、IL-8、TNF-α）명현고우건강대조조（ P ＜0．05）；여치료전비교，치료2주후，3조혈청염성인자수평균현저강저（ P ＜0．05）；차치료후연합조혈청염성인자수평균현저저우서약조화중약조（ P ＜0．05），서약조여중약조비교차이무통계학의의（ P ＞0．05）。치료전，3개병례조환인IgA수평현저저우건강대조조，IgG、IgM수평명현고우건강대조조（ P ＜0．05）；여치료전비교，치료2주후，3조IgA수평현저증가，IgG、IgM수평명현강저（ P ＜0．05）；차연합조IgA수평명현고우서약조화중약조，IgG、IgM수평현저저우서약조화중약조（ P ＜0．05），서약조여중약조비교차이무통계학의의（ P ＞0．05）。결론금백청폐농축환연합아기매소치료인동폐염지원체폐염가강저세포염성인자수평、개선면역공능가교호지개선병정，제고료효。
Objective To investigate the clinical curative effect of azithromycin combined with Qibaiqingfei pill on mycoplasma pneumonia infection in children.Methods One hundred and fifty-six children with mycoplasma pneumonia infec-tion were enrolled they were randomly assigned to three groups:Traditional Chinese medicine group, western medicine group, joint groups, and each group with 52 cases.Selected the same period 52 cases of healthy children as healthy control group, western medicine group were treated with azithromycin, Chinese medicine group received oral Qibaiqingfei pill, the joint group reveived oral azithromycin combined with Qibaiqingfei pill.Serum inflammatory factors between the 4 groups ( IL-6, IL-8, TNF-α) and immunoglobulin ( IgA, IgG, IgM) level were detected.Results After 2 weeks treatment, joint group, western medicine group and traditional Chinese medicine group’s efficiency were 98.1%(51 /52), 84.6%(44/52), 90.4%(47/52);and compared with joint group, western medicine group and Chinese medicine group were lower, the difference was statistically significant ( P <0.05).Compared with joint group, western medicine group and Chinese medicine group’ s cough disappearance time, fever disappeared time, pulmonary rales disappear time, X-ray infiltration shadow disappearance time and hospitalization time revealed statistically significant differences ( P <0.05), and no statistically significant differ-ences were found between Western medicine group and traditional Chinese medicine group ( P >0.05).Before treatment, disease group’s serum inflammatory factor levels (IL-6, IL-8, TNF-α) were significantly higher than those in healthy control group ( P <0.05);compared with before treatment, 2 weeks after treatment, 3 groups’ serum inflammatory factor levels sig-nificantly reduced ( P <0.05);and after treatment, joint group’s serum inflammatory factor levels were significantly lower than those in the Western group and traditional Chinese medicine group ( P <0.05) , western medicine group and traditional Chinese medicine group showed no statistical significance ( P >0.05).Before treatment, the disease group’s IgA level was significantly lower than that in healthy control group, IgG and IgM levels were significantly higher than those in healthy control group ( P <0.05); compared with before treatment, 2 weeks after treatment, 3 groups’ IgA level was significantly in-creased, level of IgG and IgM wer significantly reduced ( P <0.05);and the joint groups’s IgA level was significantly high-er than that of groups of Western medicine and traditional Chinese medicine, level of IgG and IgM were significantly lower than that of Western medicine group and traditional Chinese medicine group ( P <0.05) , western medicine group and traditional Chinese medicine group showed no statistical significance ( P >0.05).Conclusion It demonstrated that the Qibaiqingfei pill combined with azithromycin in treatment of children with Mycoplasma pneumonia pneumonia could reduce inflammatory cell factor level, improve immune function and the condition.